Background The degree of immune infiltration in tumors, especially CD8+ T cells, greatly
impacts patient disease course and response to interventional immunotherapy. Enhancement …

Circulating tumor-derived exosomes (TEX) interact with a variety of cells in cancer-bearing
hosts, leading to cellular reprogramming which promotes disease progression. To study TEX …

Very late antigen-4 (VLA-4; also known as integrin α 4 β 1 ) is expressed at high levels in
aggressive and metastatic melanoma tumors and may provide an ideal target for imaging and …

The ability of dendritic cells (DC) to mediate CD4+ T cell help for cellular immunity is guided
by instructive signals received during DC maturation, as well as the resulting pattern of DC …

Original research: Dendritic cell vaccines targeting tumor blood vessel antigens in
combination with dasatinib induce therapeutic immune responses in patients with checkpoint-…

Melanoma is the deadliest type of skin cancer with one of the fastest increasing incidence
rates among solid tumors. The use of checkpoint inhibitors (eg αPD-1 antibody) has recently …

Bipolar affective disorder (BPAD) are life-long disorders that account for significant morbidity
in afflicted patients. The etiology of BPAD is complex, combining genetic and environmental …

The ability of HIV-1 to rapidly accumulate mutations provides the virus with an effective means
of escaping CD8+ CTL responses. In this study, we describe how subtle alterations in CTL …

… Mailliard RB, Smith KN, Fecek RJ, Rappocciolo G, Nascimento EJ, Marques ET, Watkins SC,
Mullins JI, Rinaldo CR. 2013. Selective induction of CTL helper rather than … Ronald J. Fecek …

Recent advances in immunotherapy have enabled rapid evolution of novel interventional
approaches designed to reinvigorate and expand patient immune responses against cancer. …