Purpose The trial objectives were to identify the maximum-tolerated dose (MTD) of first-line
gemcitabine plus nab-paclitaxel in metastatic pancreatic adenocarcinoma and to provide …

Objectives: Florbetapir F 18 PET can image amyloid-β (Aβ) aggregates in the brains of living
subjects. We prospectively evaluated the prognostic utility of detecting Aβ pathology using …

Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only
a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T …

There is a need for in vivo diagnostic imaging probes that can noninvasively measure tumor-infiltrating
CD8+ leukocytes. Such imaging probes could be used to predict early response …

Background— Successful autologous skeletal myoblast transplantation into infarcted
myocardium in a variety of animal models has demonstrated improvement in cardiac function. We …

Purpose: This phase Ib study evaluated the safety and tolerability of PEGylated human
recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established …

Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is an independent predictor
of poor outcomes subsequent to surgical resection or liver transplantation (LT); however, …

Background Epigenetic alterations have been strongly associated with tumour formation and
resistance to chemotherapeutic drugs, and epigenetic modifications are an attractive target …

Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma
of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor …

Brain metastasis (BM) can affect ∼ 25% of nonsmall cell lung cancer (NSCLC) patients during
their lifetime. Efforts to characterize patients that will develop BM have been disappointing…