User profiles for Romain Bejot

Romain Bejot, PhD

Ipsen
Verified email at ipsen.com
Cited by 640

Fluorous synthesis of 18F radiotracers with the [18F] fluoride ion: nucleophilic fluorination as the detagging process.

R Bejot, T Fowler, L Carroll, S Boldon… - … (International ed. in …, 2009 - ora.ox.ac.uk
Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to
be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups …

Batch‐mode microfluidic radiosynthesis of N‐succinimidyl‐4‐[18F]fluorobenzoate for protein labelling

R Bejot, AM Elizarov, E Ball, J Zhang… - Journal of Labelled …, 2011 - Wiley Online Library
The batch microfluidic technology is a promising system for sequential chemical steps combining
the advantages of micro‐scale reactions, while addressing some shortcomings of flow‐…

Convergent 18 F radiosynthesis: a new dimension for radiolabelling

L Li, MN Hopkinson, RL Yona, R Bejot, AD Gee… - Chemical …, 2011 - pubs.rsc.org
The availability of radiolabelled probes is important for in vivo studies by positron emission
tomography (PET). Among the frontier challenges in 18F-radiochemistry are the …

The traceless Staudinger ligation for indirect 18 F-radiolabelling

L Carroll, S Boldon, R Bejot, JE Moore… - Organic & …, 2011 - pubs.rsc.org
The Staudinger ligation of phosphine-substituted thioesters with 18F-fluoroethylazide has
been successfully applied to access 18F-labelled molecules in radiochemical yields …

A fluorous and click approach for screening potential PET probes: evaluation of potential hypoxia biomarkers

R Bejot, L Carroll, K Bhakoo, J Declerck… - Bioorganic & medicinal …, 2012 - Elsevier
Radiopharmaceuticals for nuclear imaging are essentially targeting molecules, labeled with
short-lived radionuclides (eg, F-18 for PET). A significant drawback of radiopharmaceuticals …

Pre-clinical evaluation of a 3-nitro-1, 2, 4-triazole analogue of [18F] FMISO as hypoxia-selective tracer for PET

R Bejot, V Kersemans, C Kelly, L Carroll… - Nuclear medicine and …, 2010 - Elsevier
Hypoxia in solid tumours is associated with the promotion of various metabolic mechanisms
and induces resistance to radio- and chemotherapy. Non-invasive positron emission …

Stereoselective transformations of trihalomethylcarbinols induced by chromous chloride

R Bejot, S Tisserand, LM Reddy… - Angewandte Chemie …, 2005 - Wiley Online Library
(Z/E> 99: 1)[d] 12[f] 0 13 [g] 1k[f] 0 14[f] 0 [a] Yields for isolated materials after purification by
column chromatography, unless otherwise stated.[b] Yields calculated from 1H NMR …

Fe (0)-mediated synthesis of tri-and tetra-substituted olefins from carbonyls: An environmentally friendly alternative to Cr (II)

JR Falck, R Bejot, DK Barma… - The Journal of …, 2006 - ACS Publications
Fe(0) was investigated as a cost-effective, environmentally friendly alternative to Cr(II) for the
olefination of carbonyls by activated polyhalides. In many instances, Fe(0) was equivalent …

[HTML][HTML] 177Lu-OPS201 targeting somatostatin receptors: in vivo biodistribution and dosimetry in a pig model

…, B Kjærgaard, L Jødal, H Bouterfa, R Bejot… - EJNMMI research, 2016 - Springer
Background 177 Lu is used in peptide receptor radionuclide therapies for the treatment of
neuroendocrine tumors. Based on the recent literature, SST2 antagonists are superior to …

Ring Expansion/Homologation−Aldehyde Condensation Cascade Using tert-Trihalomethylcarbinols

…, A Bandyopadhyay, S Kamila, R Akella, R Bejot… - Organic …, 2006 - ACS Publications
Treatment of cyclic tert-trihalomethylcarbinols with CrCl 2 in THF/HMPA in the presence of
aryl or aliphatic aldehydes initiates a cascade sequence of one carbon ring expansion−…