User profiles for Rolf Bjerkvig
Rolf BjerkvigProfessor, University of Bergen Verified email at uib.no Cited by 26772 |
[HTML][HTML] Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC-…
resistance have been challenged in brain tumors. Here we report that cells expressing CSC-…
Whole genomes redefine the mutational landscape of pancreatic cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
We performed whole-genome sequencing and copy number variation (CNV) analysis of …
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
…, L Stuhr, A Molven, R Bjerkvig… - … journal of cancer, 2008 - Wiley Online Library
CD133 is a cell surface marker expressed on progenitors of haematopoietic and endothelial
cell lineages. Moreover, several studies have identified CD133 as a marker of brain tumor‐…
cell lineages. Moreover, several studies have identified CD133 as a marker of brain tumor‐…
DNA methylation-based classification of central nervous system tumours
…, A Becker, M Preusser, C Haberler, R Bjerkvig… - Nature, 2018 - nature.com
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …
For the approximately 100 known tumour types of the central nervous system, standardization …
[PDF][PDF] Critical appraisal of the side population assay in stem cell and cancer stem cell research
The "Side Population" (SP) discrimination assay is a flow cytometry method used to detect
stem cells based on the dye efflux properties of ABC transporters. We discuss the SP assay …
stem cells based on the dye efflux properties of ABC transporters. We discuss the SP assay …
Local endostatin treatment of gliomas administered by microencapsulated producer cells
…, MHB Hjelstuen, O Haraldseth, R Bjerkvig - Nature …, 2001 - nature.com
We describe a technique for the treatment of malignant brain tumors based on local delivery
of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in …
of the anti-angiogenic protein endostatin from genetically engineered cells encapsulated in …
The origin of the cancer stem cell: current controversies and new insights
Most tumours are derived from a single cell that is transformed into a cancer-initiating cell (cancer
stem cell) that has the capacity to proliferate and form tumours in vivo. However, the …
stem cell) that has the capacity to proliferate and form tumours in vivo. However, the …
Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: putting the research field on track–letter
Several groups, including ours, have published results showing spontaneous transformation
of human mesenchymal stem cells (MSC). Recently, we reported in this journal …
of human mesenchymal stem cells (MSC). Recently, we reported in this journal …
Long-term cultures of bone marrow–derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation
…, JC Tonn, R Goldbrunner, PE Lønning, R Bjerkvig… - Cancer research, 2009 - AACR
Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating
into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell…
into specialized cell types. Due to this ability, hMSC are currently being evaluated for cell…
EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
…, RGW Verhaak, F Winkler, R Bjerkvig… - Neuro …, 2018 - academic.oup.com
Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …