MBq) of [6-3Hjthymidine (3H-Thd, Amersham Japan Ltd., Ja pan) and killed 1 hr later. The
tumor was quickly dissected and prepared for frozen sectioning as reported previously (18). In …

… KubotaK, IshiwataK, Kubota R, et at. Tracer feasibilityfor monitoring tumor radiotherapy:a
quadrupletracer study with fluorine-18-fluorodeox yglucose or fluorine-18-fluorodeoxyuridine,l-[…

A substantial amount of macrophage infiftrationoccurs in both human and animaltumors. We
previouslyshowed that 2-deoxy 2-[1@ FJfluoro-D-gIucose ([18FJFDG) uptake was higher In …

Tritium-3-Met (specificactivityof 7.3 GBq/mmol) was pur chased from Du Pont-NEN Research
Products (Wilmington, DE) and 14C-Leu (specific activity of 1.92 GBq/mmol) from ICN Bio …

Theuptakebymacrophagesandothercellularcomponentswas low. Theuptakewashigherintheh@
htyprollferathietumorbut did not reflect protsin synthesis. The rapid and slow gro@ ng …

MATERIALSAND METhODS Radiopharmaceuticals 2-Deoxy-2-['8F] fluoro-D-glucose (â€
8FDG) and 2'-deoxy-5-[†8F] fluorouridine (†8FdUrd) were synthesized using an auto …

Recently, new cell biological tech niques of flow cytometry have been introduced, where
DNA content of cells in suspension can be analyzed and the percentage of proliferating …

The three compounds,[18FIFDG,[@ H] Thdand [1@ l] BSA, showed different heterogeneous
patterns of distributionwithin tumor tissue sections in neoplasticand non-neoplasticcellular …

MATERIALS AND METhODS The experimental protocol was approved by the Laboratory
Animal Care and Use Committee of Tohoku University. Radiopharmaceuticals Fluorine-l 8-Phe …

Brain and tumor uptake of l-[methyl- 3 H]methionine ( 3 H-Met), l-[1- 14 C]leucine ( 14 C-Leu)
and l-2-[ 18 F]fluorotyrosine ( 18 F-Tyr) and their incorporation into the acid-precipitable …