Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

…, N Dimopoulos, T Luke, R Murphy… - Proceedings of the …, 2004 - National Acad Sciences
NY-ESO-1 is a “cancer-testis” antigen expressed in many cancers. ISCOMATRIX is a
saponin-based adjuvant that induces antibody and T cell responses. We performed a placebo-…

Developing alternative frameworks for exploring intercultural learning: a critique of Hofstede's cultural difference model

P Signorini, R Wiesemes, R Murphy - Teaching in Higher …, 2009 - Taylor & Francis
Hofstede's model of cultural difference has been used widely for exploring aspects of culture
in educational settings. In this paper, we review Hofstede's model and explore some of its …

A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

…, G Ritter, MW Brechbiel, R Murphy… - Proceedings of the …, 2007 - National Acad Sciences
An array of cell-surface antigens expressed by human cancers have been identified as
targets for antibody-based therapies. The great majority of these antibodies do not have …

Professional tears: developing emotional intelligence around death and dying in emergency work

C Bailey, R Murphy, D Porock - Journal of clinical nursing, 2011 - Wiley Online Library
Aims and objectives. This paper explores how emergency nurses manage the emotional
impact of death and dying in emergency work and presents a model for developing expertise in …

The nominal group technique: extending the evaluation of students' teaching and learning experiences

M Chapple, R Murphy - Assessment & Evaluation in Higher …, 1996 - Taylor & Francis
Obtaining and evaluating student opinion about their teaching and learning experiences can,
if taken seriously, be a complex process. There are not many approaches available for …

T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein

…, H Shiku, M Monden, AA Jungbluth, G Ritter, R Murphy… - Cancer immunity, 2007 - AACR
We recently showed that vaccination with a complex of cholesterol-bearing hydrophobized
pullulan and NY-ESO-1 protein (CHP-NY-ESO-1) elicited antibody responses in 9 of 9 …

Humoral immune responses in patients vaccinated with 1–146 HER2 protein complexed with cholesteryl pullulan nanogel

…, T Shiraishi, K Akiyoshi, AM Scott, R Murphy… - Cancer …, 2008 - Wiley Online Library
The CHP‐HER2 vaccine, comprising truncated 146HER2 protein complexed with nanogels
of cholesteryl pullulan (CHP), is a novel protein antigen vaccine that elicits 146HER2‐…

HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan

…, K Akiyoshi, T Kanematsu, AM Scott, R Murphy… - Clinical cancer …, 2006 - AACR
Purpose: We developed a complex of tumor antigen protein with a novel nanoparticle
antigen delivery system of cholesteryl pullulan (CHP). To target HER2 antigen, we prepared …

Evaluating new priorities for assessment in higher education

R Murphy - Innovative assessment in higher education, 2006 - taylorfrancis.com
Recent years have seen a welcome move towards professionalising the whole approach to
the support for student learning within higher education in the UK. Staff taking up academic …

Construction, production, and characterization of humanized anti-Lewis Y monoclonal antibody 3S193 for targeted immunotherapy of solid tumors

…, KL Armour, J Rood, A Kypridis, V Kronina, R Murphy… - Cancer Research, 2000 - AACR
The Lewis Y (Le y ) antigen is a blood group-related antigen that is expressed in a high
proportion of epithelial cancers (including breast, colon, ovary, and lung cancer) and is an …