Unlike β particle–emitting isotopes, α emitters can selectively kill individual cancer cells with
a single atomic decay. HuM195, a humanized anti-CD33 monoclonal antibody, specifically …

This work describes a method for the separation and purification of Ac-225 from a Th-229
source. The procedure is based on the combination of ion exchange and extraction …

Results: Radiolabelingefficiencyof the CHX-A-DTPA-HuM195 construct with 213Biwas 78%
±10%(n= 46) after 10 min at specific activities of up to 1110MBq/mg. The immunoreactivity …

The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the
reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. …

Recent studies suggest that radioimmunotherapy (RIT) with high-linear energy transfer (LET)
radiation may have therapeutic advantages over conventional low-LET (eg., β − ) emissions…

A rapid, single-column extraction chromatographic method using commercially available
UTEVA resin has been developed for the separation of uranium, plutonium, neptunium and …

Usually, the red marrow (RM) is the first dose-limiting organ in radioimmunotherapy. However,
several studies have obtained only poor correlations between the marrow doses and the …

External source radiotherapy and beta radioimmunotherapy (RIT) are effective treatments for
lymphoid malignancies. The development of RIT with alpha emitters is attractive because of …

The separation of milligram amounts of 248 Cm from 252 Cf is presented. Essentially
isotopically pure 248 Cm was obtained from an "old" 252 Cf neutron source by acid leaching. …

A simple and robust method was developed for the chemical separation of uranium and
plutonium from mixed U/Pu/fission product solutions. The method is based on a commercially …