[99mTc] HYNIC-RGD for imaging integrin αvβ3 expression

…, M Rupprich, I Hernandez-Gonzales, T Rodrigo… - Nuclear medicine and …, 2006 - Elsevier
There has been increasing interest in peptides containing the Arg–Gly–Asp (RGD) sequence
for targeting of α v β 3 integrins to image angiogenesis. [ 18 F]Galacto-RGD has been …

Development of a high-affinity PET radioligand for imaging cannabinoid subtype 2 receptor

RP Moldovan, R Teodoro, Y Gao… - Journal of Medicinal …, 2016 - ACS Publications
Cannabinoid receptors type 2 (CB 2 ) represent a target with increasing importance for
neuroimaging due to its upregulation under various pathological conditions. Encouraged by …

Radiolabeled bombesin analogs for prostate cancer diagnosis: preclinical studies

BL Faintuch, R Teodoro, A Duatti, E Muramoto… - Nuclear medicine and …, 2008 - Elsevier
INTRODUCTION: Radionuclide imaging can be a useful tool for the diagnosis of prostate
cancer. Bombesin (BBN) is a molecule with high affinity for gastrin releasing peptide (GRP) …

Targeting and therapeutic monitoring of H3K27M-mutant glioma

…, AR Kawakibi, R Ravindran, R Teodoro… - Current oncology …, 2020 - Springer
Purpose of Review H3K27M is a frequent histone mutation within diffuse midline gliomas
and is associated with a dismal prognosis, so much so that the 2016 CNS WHO classification …

PET imaging of α7 nicotinic acetylcholine receptors: a comparative study of [18F]ASEM and [18F]DBT-10 in nonhuman primates, and further evaluation of [18F] …

…, R Pracitto, D Labaree, J Ropchan, R Teodoro… - European journal of …, 2017 - Springer
Purpose The α 7 nicotinic acetylcholine receptor (nAChR) is implicated in many
neuropsychiatric disorders, making it an important target for positron emission tomography (PET) …

Structure-Based Design, Optimization, and Development of [18F]LU13: A Novel Radioligand for Cannabinoid Receptor Type 2 Imaging in the Brain with PET

…, S Kaur, E Otikova, R Teodoro… - Journal of Medicinal …, 2022 - ACS Publications
The cannabinoid receptor type 2 (CB2R) is an attractive target for the diagnosis and therapy
of neurodegenerative diseases and cancer. In this study, we aimed at the development of a …

Synthesis, Structure–Activity Relationships, Radiofluorination, and Biological Evaluation of [18F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid …

R Teodoro, D Gündel… - Journal of Medicinal …, 2023 - ACS Publications
The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been
intensively explored due to the pronounced CB2R upregulation under various pathological …

[HTML][HTML] Improved in vivo PET imaging of the adenosine A2A receptor in the brain using [18F]FLUDA, a deuterated radiotracer with high metabolic stability

TH Lai, M Toussaint, R Teodoro… - European journal of …, 2021 - Springer
Purpose The adenosine A 2A receptor has emerged as a therapeutic target for multiple
diseases, and thus the non-invasive imaging of the expression or occupancy of the A 2A receptor …

[HTML][HTML] Radiosynthesis and biological evaluation of [18F]AG-120 for PET imaging of the mutant isocitrate dehydrogenase 1 in glioma

…, B Wenzel, S Dukić-Stefanović, R Teodoro… - European Journal of …, 2023 - Springer
Glioma are clinically challenging tumors due to their location and invasiveness nature, which
often hinder complete surgical resection. The evaluation of the isocitrate dehydrogenase …

[HTML][HTML] Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain

R Teodoro, D Gündel, W Deuther-Conrad… - International Journal of …, 2021 - mdpi.com
Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for
neurodegenerative diseases and cancer. Aiming at the development of a positron emission …