KRAS mutation is a hallmark of pancreatic ductal adenocarcinoma (PDA) but remains an
intractable pharmacologic target. Consequently, defining RAS effector pathway(s) required for …

Serine proteases are proteolytic enzymes that are involved in the regulation of various
physiological processes. We generated mice lacking the membrane-anchored channel-activating …

Full transcriptional activity of the nuclear, DNA-bound form of NF-κB requires additional
posttranslational modifications. In this study, we systematically mapped the T cell costimulation-…

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are
highly dependent on nutrients in order to duplicate their cell mass during each cell division. …

Thyroid malignancies are the most common type of endocrine tumors. Of the various
histologic subtypes, anaplastic thyroid carcinoma (ATC) represents a subset of all cases but is …

Mutated BRAF is detected in approximately 45% of papillary thyroid carcinomas (PTC). To
model PTC, we bred mice with adult-onset, thyrocyte-specific expression of BRAF V600E . …

Altered serine protease activity is associated with skin disorders in humans and in mice.
The serine protease channel-activating protease-1 (CAP1; also termed protease serine S1 …

The extracellular effects of the endocannabinoids anandamide and 2-arachidonoyl glycerol
are terminated by enzymatic hydrolysis after crossing cellular membranes by facilitated …

Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino
acids across the plasma membrane. While LAT1 is overexpressed in a variety of human …

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers,
with a median survival of only three to six months. Standard treatment options and even …