The influence of cannabis on mental health receives growing scientific and political attention.
An increasing demand for treatment of cannabis dependence has refueled the discussion …

A major pathological hallmark of Alzheimer's disease is accumulation of amyloid-β in senile
plaques in the brain. Evidence is accumulating that decreased clearance of amyloid-β from …

Purpose P-glycoprotein (Pgp) is an efflux transporter involved in transport of several compounds
across the blood–brain barrier (BBB). Loss of Pgp function with increasing age may be …

Purpose Due to the restricted expression of α v β 3 in tumours, α v β 3 is considered a suitable
receptor for tumour targeting. In this study the α v β 3 -binding characteristics of 68 Ga-…

Purpose: To evaluate whether, in patients with non–small cell lung carcinoma (NSCLC),
tumor uptake of [ 11 C]erlotinib can be quantified and imaged using positron emission …

Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide
([ 18 F] DPA-714) binds to the 18-kDa translocator protein (TSPO) …

Monoclonal antibodies (mAbs) against the epidermal growth factor receptor (EGFR) are
used in the treatment of advanced colorectal cancer (mCRC). Approximately 50% of patients …

There is evidence that P-glycoprotein (P-gp) in the blood–brain barrier (BBB) may be involved
in the aetiology of neurological disorders. For quantification of P-gp function in vivo, (R)-[ …

Background The mechanism of synaptic loss in Alzheimer’s disease is poorly understood
and may be associated with tau pathology. In this combined positron emission tomography (…

Neuroinflammation, in particular activation of microglia, is thought to play an important role
in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X …