cRGD-functionalized, DOX-conjugated, and 64Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging

…, SA Hurley, Y Xiao, Y Yang, Y Zhang, RJ Nickles… - Biomaterials, 2011 - Elsevier
Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were
developed for targeted drug delivery and positron emission tomography/magnetic resonance …

Myocardial free fatty acid and glucose use after carvedilol treatment in patients with congestive heart failure

…, TR DeGrado, DC Russell, P Stanko, RJ Nickles… - Circulation, 2001 - Am Heart Assoc
Background—Use of β-adrenoreceptor blockade in the treatment of heart failure has been
associated with a reduction in myocardial oxygen consumption and an improvement in …

An evaluation of myocardial fatty acid and glucose uptake using PET with [18F] fluoro-6-thia-heptadecanoic acid and [18F] FDG in patients with congestive heart …

…, DC Russell, P Stanko, RJ Nickles… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Understanding the metabolic consequences of heart failure is important in evaluating potential
mechanisms for disease progression and assessing targets for therapies designed to …

In vivo targeting and positron emission tomography imaging of tumor vasculature with 66Ga-labeled nano-graphene

…, Y Zhang, JW Engle, TR Nayak, CP Theuer, RJ Nickles… - Biomaterials, 2012 - Elsevier
The goal of this study was to employ nano-graphene for tumor targeting in an animal tumor
model, and quantitatively evaluate the pharmacokinetics and tumor targeting efficacy through …

Cancer-targeted optical imaging with fluorescent zinc oxide nanowires

…, J Shi, Y Yang, Y Zhang, JW Engle, RJ Nickles… - Nano …, 2011 - ACS Publications
Herein we demonstrate that intrinsically fluorescent zinc oxide (ZnO) nanowires (NWs) can
be adopted for molecularly targeted imaging of cancer cells, after they are functionalized to …

[HTML][HTML] Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles

…, R Hernandez, SA Graves, RJ Nickles… - … (Deerfield Beach, Fla …, 2015 - ncbi.nlm.nih.gov
Here, we demonstrate that a simple nanoparticle can be used as a contrast agent for
biomedical imaging in six different modalities. Near infrared (NIR) fluorescence (FL), NIR-to-NIR …

[HTML][HTML] Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging

…, W Xu, Y Yang, Y Zhang, JW Engle, RJ Nickles… - Theranostics, 2012 - ncbi.nlm.nih.gov
A multifunctional gold nanorod (GNR)-based nanoplatform for targeted anticancer drug
delivery and positron emission tomography (PET) imaging of tumors was developed and …

Intrinsically germanium‐69‐labeled iron oxide nanoparticles: synthesis and in‐vivo dual‐modality PET/MR imaging

…, H Luo, ME Meyerand, RJ Nickles… - Advanced …, 2014 - Wiley Online Library
Inspired by these, we hypothesized that using a suitable water soluble metal oxide as a
platform, 69Ge-labeled metal oxides could be synthesized simply by mixing metal oxide with …

In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

…, EB Ehlerding, S Shi, CP Theuer, RJ Nickles… - ACS …, 2015 - ACS Publications
Actively targeted theranostic nanomedicine may be the key for future personalized cancer
management. Although numerous types of theranostic nanoparticles have been developed in …

Simultaneous production of high specific activity 64Cu and 61Co with 11.4 MeV protons on enriched 64Ni nuclei

MA Avila-Rodriguez, JA Nye, RJ Nickles - Applied Radiation and Isotopes, 2007 - Elsevier
The 64 Cu and 61 Co radionuclides were produced simultaneously by irradiation of
enriched 64 Ni on a low energy proton-only cyclotron. Nickel targets were prepared by …