The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular
matter have led to debate about contents and functional properties of exosomes. Here, we …

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus
(Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 …

Extensive genomic characterization of human cancers presents the problem of inference
from genomic abnormalities to cancer phenotypes. To address this problem, we analysed …

The last decade has seen a sharp increase in the number of scientific publications describing
physiological and pathological functions of extracellular vesicles (EVs), a collective term …

Background/Aims: Several clinical, epidemiological, and animal studies indicate that nonsteroidal
anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal cancer. A likely …

Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence
on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed to …

Publisher Summary This chapter focuses on epidermal growth factor (EGF) receptor ligands.
The mammalian ligands that bind the EGF receptor (EGFR [HER1, Erb-B1]) include EGF, …

Transforming growth factor-α (TGF-α) is a polypeptide which is structurally related to epidermal
growth factor (EGF) 1,2 and binds to the EGF receptor 3,4 . TGF-α synthesis occurs in a …

✓ Stereotactic radiosurgery successfully obliterates carefully selected arteriovenous
malformations (AVM's) of the brain. In an initial 3-year experience using the 201-source cobalt-60 …

A considerable amount of evidence collected from several different experimental systems
indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large …