Comparison of [11C]-(R)-PK 11195 and [11C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission …
…, J Hong, CL Morse, SS Zoghbi, RL Gladding… - Neuroimage, 2010 - Elsevier
Ten percent of humans lack specific binding of [ 11 C]PBR28 to 18 kDa translocator protein (TSPO),
a biomarker for inflammation. “Non-binders” have not been reported using another …
a biomarker for inflammation. “Non-binders” have not been reported using another …
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
…, JS Liow, SS Zoghbi, R Gladding… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11 C-MePPEP, a PET ligand for CB 1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
[HTML][HTML] The PET radioligand [11C] MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
…, AK Chesterfield, CC Felder, RL Gladding… - …, 2008 - nature.com
The cannabinoid CB 1 receptor is one of the most abundant G protein-coupled receptors in
the brain and is a promising target of therapeutic drug development. Success of drug …
the brain and is a promising target of therapeutic drug development. Success of drug …
Synthesis and evaluation of translocator 18 kDa protein (TSPO) positron emission tomography (PET) radioligands with low binding sensitivity to human single …
…, Y Zhang, KJ Jenko, RL Gladding… - ACS chemical …, 2014 - ACS Publications
The imaging of translocator 18 kDa protein (TSPO) in living human brain with radioligands
by positron emission tomography (PET) has become an important means for the study of …
by positron emission tomography (PET) has become an important means for the study of …
[HTML][HTML] PET measurement of cyclooxygenase-2 using a novel radioligand: upregulation in primate neuroinflammation and first-in-human study
…, JA Montero Santamaria, RL Gladding… - Journal of …, 2020 - Springer
Background Cyclooxygenase-2 (COX-2), which is rapidly upregulated by inflammation, is a
key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory …
key enzyme catalyzing the rate-limiting step in the synthesis of several inflammatory …
Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function
…, J Hong, N Seneca, E Tuan, RL Gladding… - Journal of medicinal …, 2008 - ACS Publications
[ 11 C]Loperamide has been proposed for imaging P-glycoprotein (P-gp) function with
positron emission tomography (PET), but its metabolism to [N-methyl- 11 C]N-desmethyl-…
positron emission tomography (PET), but its metabolism to [N-methyl- 11 C]N-desmethyl-…
11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux
…, E Tuan, N Lazarova, RL Gladding… - Journal of nuclear …, 2008 - Soc Nuclear Med
Loperamide, an opiate receptor agonist, does not cross the blood–brain barrier because it
is a substrate for the permeability-glycoprotein (P-gp) efflux pump. We evaluated 11 C-…
is a substrate for the permeability-glycoprotein (P-gp) efflux pump. We evaluated 11 C-…
Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain
…, JP Gourley, J Hong, JL Musachio, R Gladding… - Synapse, 2007 - Wiley Online Library
Peripheral benzodiazepine receptors (PBRs) are upregulated on activated microglia and
are, thereby, biomarkers of cellular inflammation in brain. We recently developed two PET …
are, thereby, biomarkers of cellular inflammation in brain. We recently developed two PET …
Evaluation of two potent and selective PET radioligands to image COX-1 and COX-2 in rhesus monkeys
…, P Singh, C Morse, JS Liow, RL Gladding… - Journal of Nuclear …, 2018 - Soc Nuclear Med
This study assessed whether the newly developed PET radioligands 11 C-PS13 and 11 C-MC1
could image constitutive levels of cyclooxygenase (COX)-1 and COX-2, respectively, in …
could image constitutive levels of cyclooxygenase (COX)-1 and COX-2, respectively, in …
Fluoxetine administered to juvenile monkeys: effects on the serotonin transporter and behavior
…, EE Nelson, JS Liow, R Gladding… - American Journal of …, 2014 - Am Psychiatric Assoc
Objective This study examined the long-term effects of fluoxetine administered to juvenile
rhesus monkeys who, as young adults, were imaged with positron emission tomography for …
rhesus monkeys who, as young adults, were imaged with positron emission tomography for …