Background Androgen-deprivation therapy (ADT) has been the backbone of treatment for
metastatic prostate cancer since the 1940s. We assessed whether concomitant treatment with …

Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders
mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While tumor …

Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation
and to clear damaged proteins and organelles in response to stress. We report here that …

Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of
intracellular proteins and organelles. Although constitutive autophagy is a homeostatic …

Autophagy is an evolutionarily conserved, intracellular self-defense mechanism in which
organelles and proteins are sequestered into autophagic vesicles that are subsequently …

Purpose Docetaxel added to androgen-deprivation therapy (ADT) significantly increases the
longevity of some patients with metastatic hormone-sensitive prostate cancer. Herein, we …

Background Renal-cell carcinoma is highly vascular, and proliferates primarily through
dysregulation of the vascular endothelial growth factor (VEGF) pathway. We tested sunitinib and …

Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to
support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and …

Context Most newly diagnosed prostate cancers are clinically localized, and major treatment
options include surgery, radiation, or conservative management. Although conservative …

Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and
maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy-d-glucose (2DG) in …