The use of pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug
research is a promising approach that provides better understanding of drug efficacy and safety. …

Mechanism-based PK-PD models differ from conventional PK-PD models in that they contain
specific expressions to characterize, in a quantitative manner, processes on the causal …

The combination of drugs is a common practice for enhancing the efficiency of drug treatment,
but selection of the optimal combination and the optimal doses remains a matter of trial …

Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy in which
brainstem spreading depolarization may play a pivotal role, as suggested by animal studies. …

Cortical spreading depression, which plays an important role in multiple neurological disorders,
has been studied primarily with experimental models that use highly invasive methods. …

Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the
programmed death of a subset of immature cells provides a primary mechanism controlling …

Seizure-related apnea is common and can be lethal. Its mechanisms however remain
unclear and preventive strategies are lacking. We postulate that brainstem spreading …

Recent studies have shown that long-chain polyunsaturated fatty acids can prevent cardiac
arrhythmias, attributed to the reduction in excitability of cardiomyocytes, owing mainly to a …

Dravet syndrome (DS) is an epileptic encephalopathy that still lacks biomarkers for
epileptogenesis and its treatment. Dysfunction of Na V 1.1 sodium channels, which are chiefly …

Purpose: Combination therapy is often used in the treatment of seizures refractory to
monotherapy. At the same time, the pharmacodynamic mechanisms that determine the combined …