Signaling through the immune checkpoint programmed cell death protein-1 (PD-1) enables
tumor progression by dampening antitumor immune responses. Therapeutic blockade of the …

A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory
activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-…

There is a critical need for compounds that target cell surface integrin receptors for applications
in cancer therapy and diagnosis. We used directed evolution to engineer the Ecballium …

There is a critical need for molecular imaging agents to detect cell surface integrin receptors
that are present in human cancers. Previously, we used directed evolution to engineer …

Targeted contrast-enhanced ultrasound imaging is increasingly being recognized as a powerful
imaging tool for the detection and quantification of tumor angiogenesis at the molecular …

Purpose: Detection of pancreatic cancer remains a high priority and effective diagnostic tools
are needed for clinical applications. Many cancer cells overexpress integrin α v β 6 , a cell …

Fimbriae of Porphyromonas gingivalis are filamentous appendages on the cell surface and
are thought to be one of the virulence factors. The fimA gene encoding the subunit protein of …

Advances in precision molecular imaging promise to transform our ability to detect, diagnose
and treat disease. Here, we describe the engineering and validation of a new cystine knot …

We have used boron-based molecules to create novel, competitive, reversible inhibitors of
phosphodiesterase 4 (PDE4). The co-crystal structure reveals a binding configuration which …

The cyclotide MCoTI-II is a powerful trypsin inhibitor recently isolated from the seeds of
Momordica cochinchinensis, a plant member of cucurbitaceae family. We report for the first time …