We studied neuroinflammation in individuals with late-life, depression, as a risk factor for
dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants …

Introduction The deposition of neurofibrillary tangles in neurodegenerative disorders is
associated with neuronal loss on autopsy; however, their in vivo associations with atrophy across …

The PET ligand [ 18 F] AV ‐1451 was developed to bind tau pathology in Alzheimer's
disease, but increased binding has been shown in both genetic tauopathies and in semantic …

The ability to assess the distribution and extent of tau pathology in Alzheimer’s disease and
progressive supranuclear palsy in vivo would help to develop biomarkers for these …

Alzheimer’s disease and progressive supranuclear palsy (PSP) represent neurodegenerative
tauopathies with predominantly cortical versus subcortical disease burden. In Alzheimer’s …

Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer’s
disease. Understanding whether these features predict cognitive decline, alone or in …

The clinical syndromes of frontotemporal dementia are clinically and neuropathologically
heterogeneous, but processes such as neuroinflammation may be common across the disease …

Objective We tested whether in vivo neuroinflammation relates to the distinctive distributions
of pathology in Alzheimer disease (AD) and progressive supranuclear palsy (PSP). …

Frontotemporal dementia is clinically and neuropathologically heterogeneous, but
neuroinflammation, atrophy and cognitive impairment occur in all of its principal syndromes. Across …

Introduction Semantic dementia, including the semantic variant of primary progressive
aphasia (svPPA), is strongly associated with TAR-DNA binding protein 43 (TDP-43) type C …