Recent investigations of atherosclerosis have focused on inflammation, providing new insight
into mechanisms of disease. Inflammatory cytokines involved in vascular inflammation …

Background— Myeloid-related protein (MRP)-8 (S100A8) and MRP-14 (S100A9) are members
of the S100 family of calcium-modulated proteins that regulate myeloid cell function and …

Atherosclerosis, a chronic inflammatory disorder, involves both the innate and adaptive arms
of the immune response that mediate the initiation, progression, and ultimate thrombotic …

PET myocardial perfusion imaging (MPI) is increasingly being used for noninvasive detection
and evaluation of coronary artery disease. However, the widespread use of PET MPI has …

Common forms of atherosclerosis involve multiple genetic and environmental factors. While
human genome-wide association studies have identified numerous loci contributing to …

Hemodynamic shear forces are intimately linked with cardiac development, during which
trabeculae form a network of branching outgrowths from the myocardium. Mutations that alter …

Recent reports suggest dyslipidemia impairs dendritic cell (DC) function and adaptive
immunity. This study aimed to characterize the effect of hypercholesterolemia on antigen-…

CD4 + CD25 + regulatory T cells (T regs) play a major role in the maintenance of self-tolerance
and immune suppression, although the mechanisms controlling T reg development and …

Light Sheet Fluorescence Microscopy (LSFM) enables multi-dimensional and multi-scale
imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid plane …

Absolute quantitation of myocardial blood flow (MBF) by PET is an established method of
analyzing coronary artery disease (CAD) but subject to the various shortcomings of available …