Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for
the transformation of human cells. However, the molecular mechanisms by which PP2A …

Objectives and Study Design: The advent of the rigid endonasal endoscope and the development
of functional endoscopic sinus surgery (FESS) technique have awakened interest in …

Background Oral (mobile) tongue squamous cell carcinoma (SCC) is characterized by a highly
variable prognosis in early‐stage disease (T1/T2 N0M0). The ability to classify early oral …

Head and neck squamous cell carcinomas (HNSCCs) frequently disseminate to regional
lymph nodes. To investigate the possible mechanisms involved, we studied the expression of …

Collagenase-3 (MMP-13) is a human matrix metalloproteinase specifically expressed by
transformed squamous epithelial cells, ie squamous cell carcinoma (SCC) cells in culture and …

Purpose: To find molecular markers from expression profiling data to predict recurrence of
laryngeal cancer after radiotherapy. Experimental Design: We generated gene expression …

Background The tumor suppressor Programmed Cell Death 4 (PDCD4) has been found to
be under-expressed in several cancers and associated with disease progression and …

In several recent studies, CD44 expression has been associated with aggressive behavior in
cancers of different types. CD44 expression is also linked to cancer stem cells, which have …

Despite early diagnosis and treatment, almost 20 % of patients with early-stage (cT1-cT2N0)
oral tongue squamous cell carcinoma (OTSCC) still die of their disease. The prognosis of …

A growing body of evidence suggests that components of the tumor microenvironment,
including cancer-associated fibroblasts (CAF), may modulate the treatment sensitivity of tumor …