Purpose The cannabinoid type 2 receptor (CB 2 R) is expressed by immune cells such as
monocytes and macrophages. In the brain, CB 2 R is primarily found on microglia. CB 2 R …

Phosphodiesterase 10A (PDE10A) belongs to a family of enzymes that hydrolyze cyclic
adenosine monophosphate (cAMP) and cyclic guanosine monophosphate. PDE10A is highly …

Purpose The type 2 cannabinoid receptor (CB2R) is part of the human endocannabinoid
system and is involved in central and peripheral inflammatory processes. In vivo imaging of the …

… Rawaha Ahmad and Karolien Goffin managed the literature searches, statistical analyses
and they also wrote the first draft of the manuscript. All authors contributed to and have …

Phosphodiesterase 10A (PDE10A) plays a central role in striatal signaling and is implicated
in several neuropsychiatric disorders, such as movement disorders and schizophrenia. We …

The clinical phenotype of Huntington's disease (HD) consists of motor, cognitive and psychiatric
symptoms, of which irritability is an important manifestation. Our aim was to identify the …

Lung cancer is still the major cause of cancer-related mortality around the globe. The
interplay of permanent genetic and dynamic epigenetic changes leads to the onset and …

Purpose The endocannabinoid system plays a regulatory role in a number of physiological
functions, including motor control but also mood, emotion, and cognition. A number of …

Purpose Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP-hydrolysing enzyme with a
central role in striatal signalling and implicated in neuropsychiatric disorders such as …

Many Huntington disease (HD) mutation carriers already have cognitive and psychiatric
symptoms in the premanifest (premotor) phase of the disease (pre-HD), but the molecular …