A concise radiosynthesis of the tau radiopharmaceutical, [18F]T807

…, DL Yokell, PA Rice, RN Jackson… - Journal of Labelled …, 2013 - Wiley Online Library
Fluorine‐18 labeled 7‐(6‐fluoropyridin‐3‐yl)‐5H‐pyrido[4,3‐b]indole ([ 18 F]T807) is a
potent and selective agent for imaging paired helical filaments of tau and is among the most …

Microfluidic continuous-flow radiosynthesis of [18 F] FPEB suitable for human PET imaging

SH Liang, DL Yokell, RN Jackson, PA Rice… - …, 2014 - pubs.rsc.org
The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([18F]FPEB)
for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with …

First Human Use of a Radiopharmaceutical Prepared by Continuous-Flow Microfluidic Radiofluorination: Proof of Concept with the Tau Imaging Agent [18F]T807

…, MD Normandin, PA Rice, RN Jackson… - Molecular …, 2014 - journals.sagepub.com
Despite extensive preclinical imaging with radiotracers developed by continuous-flow
microfluidics, a positron emission tomographic (PET) radiopharmaceutical has not been reported …

Development and evaluation of novel LRRK2 inhibitors as PET ligands for in vivo imaging of LRRK2

YS Ding, D Clancy, G Carlucci, N Ramos, R Jackson… - 2019 - Soc Nuclear Med
1105 Objectives: There is an urgent need for the development of Parkinson9s disease (PD)
treatments that can slow disease progression. LRRK2 (leucine-rich repeat kinase 2) has …

First human use of the tau radiopharmaceutical [18F] T807 by microfluidic flow chemistry

T Collier, D Yokell, P Rice, R Jackson, T Shoup… - 2014 - Soc Nuclear Med
1246 Objectives Despite extensive preclinical imaging with radiotracers prepared by
continuous-flow microfluidics, there is still no published PET radiopharmaceutical prepared for …

[HTML][HTML] Evidence For Cannabidiol Modulation of Serotonergic Transmission in a Model of Osteoarthritis via in vivo PET Imaging and Behavioral Assessment

…, Z Gironda, O Mishkit, J Mroz, R Jackson… - … journal of innovative …, 2022 - ncbi.nlm.nih.gov
Background: Preclinical studies indicate that cannabidiol (CBD), the primary nonaddictive
component of cannabis, has a wide range of reported pharmacological effects such as …

Study of ALS and RAGE Using [11C] PBR28: Mechanisms and Therapeutic Opportunities

…, M MacLean, Z Youss, O Mishkit, D Clancy, R Jackson… - 2020 - Soc Nuclear Med
212 Objectives: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder
that is characterized by selective degeneration of both upper and lower motor neurons, …

Synthesis of 3‐[18F]Fluoro‐5‐(2‐Pyridinylethynyl)Benzonitrile ([18F]FPEB)

SH Liang, DL Yokell, RN Jackson… - … for Positron Emission …, 2015 - Wiley Online Library
Glutamatergic signaling abnormalities have long been implicated in several neuropsychiatric
disorders. Several lines of evidence point to a critical role for metabotropic glutamate …

Millimeter-Sized Mageto-Elastic (Msme) Sensors for Bioterrorism Agent Detection

R Jackson, R Mutharasan - The 2005 Annual Meeting, 2005 - aiche.confex.com
Amorphous ferromagnetic ribbons iron-rich alloy ribbons (Fe40Ni38Mo4B18, Metglas 2826)
have a high mechanical tensile strength (~ 1000-1700 MPa), and a high magnetoelastic …

Non-invasive PET Imaging of CDK4/6 Expression in Breast Cancer Models

N Ramos, J Baquero-Buitrago, R Jackson, F Boada… - 2019 - Soc Nuclear Med
1036 Introduction: Breast cancer is a worldwide health issue with about 1 million new cases
every year. Dysregulated cellular proliferation, a common feature to all human cancers, is a …