Focal cerebral ischemia leads to an inflammatory reaction involving an overexpression of
the peripheral benzodiazepine receptor (PBR)/18-kDa translocator protein (TSPO) in the …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. Activated
microglia/macrophages play a key role in the immunopathogenesis of MS and its corresponding …

FPyME (1-[3-(2-fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione) was designed as a [ 18 F]fluoropyridine-based
maleimide reagent for the prosthetic labeling of peptides and proteins via …

Characterizing tumor heterogeneity using texture indices derived from PET images has shown
promise in predicting treatment response and patient survival in some types of cancer. Yet…

Efficient methods for tumor targeting are eagerly awaited and must satisfy several challenges:
molecular specificity, transport through physiologic barriers, and capacity to withstand …

The labelling of single-stranded oligonucleotides with a positron or single-photon emitter
can result in valuable radiopharmaceuticals with promising applications for: (i) Imaging of …

Background Many new candidate pharmaceuticals designed to improve recovery after
stroke have been proposed recently, but there are still too few molecular imaging methods …

In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association
with DNA vaccination greatly stimulates immune responses to vaccine antigens delivered …

Inflammatory responses are closely associated with many neurologic disorders and influence
their outcome. In vivo imaging can document events accompanying neuroinflammation, …

The blood-brain barrier (BBB) permeabilities of 11 compounds were measured both in vitro
with a newly developed coculture-based model of human BBB and in vivo with positron …