Gadolinium, an obscure lanthanide element buried in the middle of the periodic table, has
in the course of a decade become commonplace in medical diagnostics. Like platinum in …

The development of nuclear magnetic resonance (NMR) imaging techniques as a clinical
diagnostic modality has prompted the need for a new class of pharmaceuticals. These drugs …

Using a one‐dimensional rapid imaging technique, we have found that injection of lanthanide
chelates such as Gd(DTPA) 2− leads to a significant decrease (50%) in rat brain signal …

PURPOSE: To evaluate the protein-binding and signal enhancement characteristics of MS-325,
a gadolinium-based magnetic resonance (MR) imaging blood pool agent that binds to …

MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently
undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to human …

Rationale and Objectives The authors evaluate MS-325, a new albumin-targeted magnetic
resonance imaging (MRI) contrast agent, for its pharmacokinetics, biodistribution, and …

Background— The advent of fibrin-binding molecular magnetic resonance (MR) contrast
agents and advances in coronary MRI techniques offers the potential for direct imaging of …

The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl)
phosphonooxymethyl] diethylenetriaminepentaacetato) (aquo)gadolinium(III)}) is a contrast …

Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast
agent has been achieved by using prodrug Gd 3+ complexes (see picture, DTPA= …

The solution structure and dynamics of lanthanide (III) complexes of diethylenetriaminepentaacetate
(DTPA) have been investigated by NMR. Two-dimensional (2D) exchange …