The inverse-electron-demand Diels–Alder cycloaddition between trans-cyclooctenes and
tetrazines is biocompatible and exceptionally fast. We utilized this chemistry for site-specific …

Highlights • Tetrazine–TCO ligation is an exceptionally rapid bioorthogonal reaction. •
Computational design of reactive dienophiles with rates> 10 6. • Rapid construction of …

Labeling biomolecules with 18 F is usually done through coupling with prosthetic groups,
which generally requires several time-consuming radiosynthetic steps resulting in low labeling …

18 F positron emission tomography (PET) has a number of attributes that make it clinically
attractive, including nearly 100% positron efficiency, very high specific radioactivity, and a …

The fast kinetics and bioorthogonal nature of the tetrazine trans-cyclooctene (TCO) ligation
makes it a unique tool for PET probe construction. In this study, we report the development of …

PhI(OAc) 2 serves as a mild and effective oxidant for the synthesis of s-tetrazine derivatives—molecules
of emerging significance to the field of bioorthogonal chemistry. This reagent …

Described is a Cu-catalyzed directed carbozincation of cyclopropenes with organozinc
reagents prepared by I/Mg/Zn exchange. This protocol broadens the scope with respect to …

Heterogeneous semiconductors are underexploited as photoredox catalysts in organic synthesis
relative to their homogeneous, molecular counterparts. Here, we report the use of metal/…

… Ramajeyam Selvaraj … Ramajeyam Selvaraj - Brown Laboratories, Department of
Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States …

The article describes the preparation of 3‐hydroxymethyl‐3‐phenylcyclopropene and
modification was reported. This compound and related, prochiral cyclopropenes served as …