D 1 receptors are the main mediators of dopamine transmission in the cortex and subserve
cognitive functions that are affected in patients with schizophrenia. Prior imaging studies …

The recent introduction of a number of new radiotracers suitable for imaging the serotonin
transporters (SERT) has radically changed the field of SERT imaging. Whereas, until recently, …

Purpose [ 11 C]NNC 112 and [ 11 C]SCH 23390 are selective positron emission tomography
(PET) tracers for visualizing dopamine D 1 receptors. It is known that both have some …

Synaptic dopamine (DA) levels seem to affect the in vivo binding of many D2 receptor
radioligands. Thus, release of endogenous DA induced by the administration of amphetamine …

Brain κ-opioid receptors (ORs) may be involved in several pathologic conditions, such as
addiction, psychosis, and seizures. (±)-4-Methoxycarbonyl-2-[(1-pyrrolidinylmethyl]-1-[(3,4-…

Rationale [ 18 F]Fallypride is a new and promising radiotracer, suitable for imaging D 2 receptors
with Positron Emission Tomography (PET) in both striatal and extrastriatal regions. The …

[ 18 F]fallypride is a new positron emission tomography (PET) dopamine D 2 receptor radiotracer
that provides visualization of D 2 receptors in both striatal and extrastriatal areas. Here, …

A selective metabotropic glutamate 1 receptor (mGlu1) antagonist was labeled with the
positron-emitting radioisotope carbon-11 and evaluated in ex vivo biodistribution studies and …

The synthesis, radiolabeling, and in vitro and in vivo evaluation of a new positron emission
tomography (PET) radioligand for the serotonin transporter (SERT), [ 11 C]2-[2-(…

… Narendran and Frankle for their interest in our study (1) and for the opportunity to address
the issues raised. The first issue is why we used distribution volume ratio and not distribution …