High specific activity iodination of γ-globulin with iodine-131 monochloride

RW Helmkamp, RL Goodland, WF Bale, IL Spar… - Cancer Research, 1960 - AACR
A technic, efficient in use of I 131 , has been developed for introducing I 131 into 4-mg. amounts
of antibody or γ-globulin protein at a level of 10 mc. I 131 per mg. protein with a resulting …

High Specific Activity Labeling of Protein with I131 by the Iodine Monochloride Method.

WF Bale, RW Helmkamp, TP Davis… - Proceedings of the …, 1966 - journals.sagepub.com
A modified iodine monochloride method suitable for preparing I 131 -labeled proteins of a
high degree of radioactivity is described, and results are given. Hydrogen peroxide present in …

I131-labeling of proteins by the iodine monochloride method

RW Helmkamp, MA Contreras, WF Bale - The International Journal of …, 1967 - Elsevier
A detailed study has been made of the iodine monochloride method of protein iodination. In
particular, the losses of I 131 , which may be incurred in the preparation of labeled γ-…

The Action of Some Benzyl Halides on Salts of Phenylnitromethane and Phenylnitro-acetonitrile

L Weisler, RW Helmkamp - Journal of the American Chemical …, 1945 - ACS Publications
A procedure for the synthesis of a hexahydro-2-oxo-4-methyl-l-furo [3, 4] imidazole isomer
has been described. This synthesis involves catalytic hydrogenation of the appropriate furan …

A radioactive label for the erythrocyte membrane

DA Sears, CF Reed, RW Helmkamp - Biochimica et Biophysica Acta (BBA) …, 1971 - Elsevier
A new radioactive reagent, diazotized [ 131 I] diiodosulfanilic acid, which binds specifically
to protein groups of the erythrocyte membrane, is described. The labeling reaction and some …

I131-labeling of proteins at high activity level with I131Cl produced by oxidation of total iodine in NaI131 preparations

RW Helmkamp, MA Contreras, MJ Izzo - The International Journal of …, 1967 - Elsevier
A procedure is described for oxidizing the total iodine in “carrier-free” NaI 131 preparations
to ICl under conditions such that the resulting solution can be used directly for production of I …

The addition reactions of certain pentadienones

EP Kohler, RW Helmkamp - Journal of the American Chemical …, 1924 - ACS Publications
The monophenyl and monomethyl esters of a-phenyl-/3-bromoß-^-chlorobenzoylethyl-phosphonic
acid havebeen prepared and their behaviors in alkaline solution studied. 2. The two …

THE SYNTHESIS OF DL-LYSINE C14 in the Epsilon Position.

…, S WOISLOWSKI, RW Helmkamp - The Journal of …, 1948 - ACS Publications
In the attempt to prepare DL-lysine labeled with C14 for use in metabolic stud-ies, our initial
efforts were directed toward the development of a method which would permit the …

The determination of 210Po and 210Bi in human urine by direct extraction on nickel

RW Helmkamp, WF Bale, V Hrynyszyn - The International Journal of …, 1979 - Elsevier
The 210 Po in relatively large volumes of dilute hydrochloric acid (900–1800 ml) and of
acidified urine (2 × 1335 to 2 × 1700 ml), spiked with equilibrated 210 Pb− 210 Bi− 210 Po, was …

Some Michael condensations involving benzyl cyanide

RW Helmkamp, LJ Tanghe, JT Plati - Journal of the American …, 1940 - ACS Publications
From the reaction mixture it is possible to isolate, in addition to the cyclohexanone derivative,
two compounds isomeric with it. These substances are evidently stereoisomers having the …