The rise of professional associations was carried out under the popular slogans of modernization
and reform, and this idealized image has continued to dominate not only the public but …

A six year randomised trial was conducted among 5139 apparently healthy male doctors to
see whether 500 mg aspirin daily would reduce the incidence of and mortality from stroke, …

There are 14 unconfounded randomised trials of antihypertensive drugs (chiefly diuretics or
beta-blockers): total 37 000 individuals, mean treatment duration 5 years, mean diastolic …

This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

An imbalance in oxygen supply and demand......................................................................... 337
Experimental evidence for possible mechanisms of benefit from beta blockade in acute MI …

… In another paper (Collins, in press), I have attempted to show that the microtranslation of
a large body of causal principles leaves, in addition to a number of pure microprinciples, …

Background Lowering of LDL cholesterol with standard statin regimens reduces the risk of
occlusive vascular events in a wide range of individuals. We aimed to assess the safety and …

Background The benefits of reducing blood pressure on the risks of major cardiovascular
disease are well established, but uncertainty remains about the comparative effects of different …

The promise of quantum computers is that certain computational tasks might be executed
exponentially faster on a quantum processor than on a classical processor 1. A fundamental …

… Collins R, Gray R, Godwin J, Peto R. Avoidance of large biases and large random errors
in the assessment of moderate treatment effects: the need for systematic overviews. Stat Med …