Vitamin D and human health: lessons from vitamin D receptor null mice

R Bouillon, G Carmeliet, L Verlinden… - Endocrine …, 2008 - academic.oup.com
The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-…

Structure-function relationships in the vitamin D endocrine system

R Bouillon, WH Okamura, AW Norman - Endocrine reviews, 1995 - academic.oup.com
I. Vitamin D Endocrine System RESEARCH directed at defining the molecular mode of
action of vitamin D is currently at its apex. There is now evidence implicating the essential …

An overview of real-time quantitative PCR: applications to quantify cytokine gene expression

…, L Overbergh, D Valckx, B Decallonne, R Bouillon… - Methods, 2001 - Elsevier
The analysis of cytokine profiles helps to clarify functional properties of immune cells, both
for research and for clinical diagnosis. The real-time reverse transcription polymerase chain …

[HTML][HTML] Intensive insulin therapy in critically ill patients

…, P Ferdinande, P Lauwers, R Bouillon - New England journal …, 2001 - Mass Medical Soc
Background Hyperglycemia and insulin resistance are common in critically ill patients, even
if they have not previously had diabetes. Whether the normalization of blood glucose levels …

[HTML][HTML] Intensive insulin therapy in the medical ICU

…, H Bobbaers, R Bouillon - New England journal …, 2006 - Mass Medical Soc
Background Intensive insulin therapy reduces morbidity and mortality in patients in surgical
intensive care units (ICUs), but its role in patients in medical ICUs is unknown. Methods In a …

Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control

G Van den Berghe, PJ Wouters, R Bouillon… - Critical care …, 2003 - journals.lww.com
… Pearson’s product-moment correlation coefficients (R), determination coefficients (R 2 ), and
Spearman’s (Rho) correlation coefficients were calculated for quantifying the relation between …

Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for …

…, JMV Barrios, JFA Díaz, JL Miranda, R Bouillon… - The Journal of steroid …, 2020 - Elsevier
“Effect of calcifediol treatment and best available therapy versus best available therapy on
intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot …

[HTML][HTML] Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

…, D Goltzman, S Kaiser, NE Cusano, R Bouillon… - Osteoporosis …, 2017 - Springer
The purpose of this review is to assess the most recent evidence in the management of
primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, …

[HTML][HTML] The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

[HTML][HTML] Vitamin D and diabetes

C Mathieu, C Gysemans, A Giulietti, R Bouillon - Diabetologia, 2005 - Springer
Vitamin D deficiency predisposes individuals to type 1 and type 2 diabetes, and receptors
for its activated form—1α,25-dihydroxyvitamin D 3 —have been identified in both beta cells …