The role of serotonin in prenatal and postnatal brain development is well documented in the
animal literature. In earlier studies using positron emission tomography (PET) with the tracer …

Several reports have indicated that cortical resection is effective in alleviating intractable
epilepsy in children with tuberous sclerosis complex (TSC). Because of the multitude of cortical …

Tuberous sclerosis complex is commonly associated with medically intractable seizures. We
previously demonstrated that high uptake of α-[ 11 C]methyl-L-tryptophan (AMT) on positron …

Recent evidence suggests disturbances of serotonin synthesis affecting the dentato-thalamo-cortical
pathway in autistic boys. We studied possible effects of such disturbances on brain …

Abnormal metabolism of tryptophan has been implicated in modulation of tumor cell proliferation
and immunoresistance. α-[ 11 C]Methyl-l-tryptophan (AMT) is a PET tracer to measure …

Background Tryptophan catabolism via the kynurenine pathway, mediated by indoleamine 2,3-dioxygenase
(IDO), is a mechanism involved in tumor immunoresistance. Positron …

INTRODUCTION: Tryptophan oxidation via the kynurenine pathway is an important
mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin …

PET of amino acid transport and metabolism may be more accurate than conventional
neuroimaging in differentiating recurrent gliomas from radiation-induced tissue changes. α- 11 C-…

Maternal intrauterine inflammation is implicated in neurodevelopmental disorders in the
offspring. Serotonin is crucial for regulating maturation in the developing brain, and maternal …

Neuropsychological studies suggest that good long-term language outcome is possible
following extensive early left-hemisphere damage. We explored the brain organization for …