Importance Myocarditis is a leading cause of sudden death in competitive athletes. Myocardial
inflammation is known to occur with SARS-CoV-2. Different screening approaches for …

Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P),
were mediators of arachidonic acid released in cells in response to interleukin-1β …

FTY720 is a potent immunomodulator drug that inhibits the egress of lymphocytes from
secondary lymphoid tissues and thymus. FTY720 is phosphorylated in vivo by sphingosine …

Previously, ceramide-1-phosphate (C1P) was demonstrated to be a potent and specific activator
of group IV cytosolic phospholipase A 2 α (cPLA 2 α) via interaction with the C2 domain. …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site of …

Previous findings from our laboratory have demonstrated that cPLA 2 α is directly activated
by the emerging bioactive sphingolipid, ceramide 1-phosphate (C-1-P) (1). In this study, a …

Holography is a photographic method that records the light dispersed from a body and then
produces a realistic image identified as three-dimensional Holograms. The hologram reflects …

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a
valuable model system to study the generation and mechanisms modulating conventional …

Little is known about the regulation of eicosanoid synthesis proximal to the activation of
cytosolic phospholipase A 2 α (cPLA 2 α), the initial rate-limiting step. The current view is that …

Previous studies in our laboratory have established ceramide kinase (CERK) as a critical
mediator of eicosanoid synthesis. To date, CERK has not been well characterized in vitro. In …