User profiles for Pradeep J. Nathan

Pradeep J. Nathan

Heptares Therapeutics Ltd and University of Cambridge
Verified email at cam.ac.uk
Cited by 17795

Amygdala–frontal connectivity during emotion regulation

…, KT Eddy, M Angstadt, PJ Nathan… - Social cognitive and …, 2007 - academic.oup.com
Successful control of affect partly depends on the capacity to modulate negative emotional
responses through the use of cognitive strategies (ie, reappraisal). Recent studies suggest …

Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study

KL Phan, DA Fitzgerald, PJ Nathan, GJ Moore… - Biological …, 2005 - Elsevier
BACKGROUND: Successful control of affect partly depends on the capacity to modulate
negative emotional responses through the use of cognitive strategies. Although the capacity to …

BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

B Lu, G Nagappan, X Guan, PJ Nathan… - Nature Reviews …, 2013 - nature.com
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark
in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of …

Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia

KL Phan, DA Fitzgerald, PJ Nathan, ME Tancer - Biological psychiatry, 2006 - Elsevier
BACKGROUND: Previous functional brain imaging studies of social anxiety have implicated
amygdala hyperactivity in response to social threat, though its relationship to quantitative …

[HTML][HTML] Oxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder

…, P Chua, M Heinrichs, JC Stout, PJ Nathan - …, 2010 - nature.com
Patients with generalized social anxiety disorder (GSAD) exhibit heightened activation of
the amygdala in response to social cues conveying threat (eg, fearful/angry faces). The …

Beyond threat: amygdala reactivity across multiple expressions of facial affect

DA Fitzgerald, M Angstadt, LM Jelsone, PJ Nathan… - Neuroimage, 2006 - Elsevier
The amygdala has been consistently isolated as a key neural substrate for processing facial
displays of affect. Recent evidence from human lesion and functional neuroimaging studies …

Cognitive effort drives workspace configuration of human brain functional networks

…, RNA Henson, ML Smith, PJ Nathan… - Journal of …, 2011 - Soc Neuroscience
Effortful cognitive performance is theoretically expected to depend on the formation of a
global neuronal workspace. We tested specific predictions of workspace theory, using graph …

The Neuropharmacology of L-Theanine(N-Ethyl-L-Glutamine) A Possible Neuroprotective and Cognitive Enhancing Agent

PJ Nathan, K Lu, M Gray, C Oliver - Journal of herbal …, 2006 - Taylor & Francis
L-theanine (N-ethyl-L-glutamine) or theanine is a major amino acid uniquely found in green
tea. L-theanine has been historically reported as a relaxing agent, prompting scientific …

Molecular imaging of the dopaminergic system and its association with human cognitive function

VL Cropley, M Fujita, RB Innis, PJ Nathan - Biological psychiatry, 2006 - Elsevier
Molecular imaging with positron emission tomography (PET) and single photon emission
computed tomography (SPECT) has recently been used to examine dopamine (DA) function …

Functional dysconnectivity of corticostriatal circuitry as a risk phenotype for psychosis

…, PJ Nathan, BR Lennox, PB Jones, J Suckling… - JAMA …, 2013 - jamanetwork.com
Importance Dysregulation of corticostriatal circuitry has long been thought to be critical in the
etiology of psychotic disorders, although the differential roles played by dorsal and ventral …