Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

Low-passage, serum-free cell lines cultured from patient tumour tissue are the gold-standard
for preclinical studies and cellular investigations of glioblastoma (GBM) biology, yet …

Glioblastomas (GBMs) are malignant central nervous system (CNS) neoplasms with a very
poor prognosis. They display cellular hierarchies containing self-renewing tumourigenic …

Glioblastoma (GBM) is a treatment-refractory central nervous system (CNS) tumour, and better
therapies to treat this aggressive disease are urgently needed. Primary GBM models that …

Pineal germinoma is rare with high cure rates following craniospinal radiotherapy. Efforts to
reduce the radiotherapy dose and field via combination with chemotherapy suggest …

Medulloblastoma in adult patients is a rare condition with limited contemporary demographic
and treatment outcome data available in an Australian population. We conducted a …

Lung cancer is the commonest cause of cancer deaths worldwide. Although strongly associated
with smoking, predisposition to lung cancer is also heritable, with multiple common risk …

104 Objectives: Glioblastoma multiforme (GBM) is the most frequent and lethal primary brain
neoplasm, with only 10% of patients surviving 5 years. EphA3 is a tumor restricted antigen …

Background The cancer genomics field has embraced the advent of precision oncology,
and vast volumes of data have been mined for biomarkers of drug actionability. While some …

Lung cancer is the commonest cause of cancer deaths worldwide. Although strongly
associated with smoking, predisposition to lung cancer is also heritable with multiple …