The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
J Sevigny, P Chiao, T Bussière, PH Weinreb… - Nature, 2016 - nature.com
Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and
neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration…
neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration…
[HTML][HTML] The influence of biological and technical factors on quantitative analysis of amyloid PET: points to consider and recommendations for controlling variability in …
ME Schmidt, P Chiao, G Klein, D Matthews… - Alzheimer's & …, 2015 - Elsevier
In vivo imaging of amyloid burden with positron emission tomography (PET) provides a
means for studying the pathophysiology of Alzheimer's and related diseases. Measurement of …
means for studying the pathophysiology of Alzheimer's and related diseases. Measurement of …
[PDF][PDF] Carbon-11-acetate PET imaging in renal disease
P Shreve, PC Chiao, HD Humes… - Journal of Nuclear …, 1995 - Soc Nuclear Med
METhODS Patients and Subjects We recruited 18patients (aged24— 68yr) from the Ann
Arbor Departmentof Veterans AffairsMedicalCenter for our study:
Arbor Departmentof Veterans AffairsMedicalCenter for our study:
Concordance between different amyloid immunoassays and visual amyloid positron emission tomographic assessment
S Janelidze, J Pannee, A Mikulskis, P Chiao… - JAMA …, 2017 - jamanetwork.com
Importance Visual assessment of amyloid positron emission tomographic (PET) images has
been approved by regulatory authorities for clinical use. Several immunoassays have been …
been approved by regulatory authorities for clinical use. Several immunoassays have been …
Amyloid PET screening for enrichment of early-stage Alzheimer disease clinical trials: experience in a phase 1b clinical trial
Amyloid positron emission tomography (PET) imaging is being investigated as a screening
tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD…
tool to identify amyloid-positive patients as an enrichment strategy for Alzheimer disease (AD…
Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer's disease
J Sevigny, P Chiao, T Bussière, PH Weinreb… - Nature, 2017 - nature.com
Figure 1 of our original Article illustrated that treatment with aducanumab reduced human
brain amyloid-β plaques in a dose-dependent fashion as measured by florbetapir positron …
brain amyloid-β plaques in a dose-dependent fashion as measured by florbetapir positron …
Impact of reference and target region selection on amyloid PET SUV ratios in the phase 1b PRIME study of aducanumab
P Chiao, BJ Bedell, B Avants… - Journal of Nuclear …, 2019 - Soc Nuclear Med
SUV ratios (SUVRs) are commonly used to quantify tracer uptake in amyloid-β PET. Here,
we explore the impact of target and reference region-of-interest (ROI) selection on SUVR …
we explore the impact of target and reference region-of-interest (ROI) selection on SUVR …
Noninvasive PK11195‐PET image analysis techniques can detect abnormal cerebral microglial activation in Parkinson's disease
…, C Henchcliffe, SA Gauthier, PC Chiao… - Journal of …, 2018 - Wiley Online Library
BACKGROUND AND PURPOSE Neuroinflammation has been implicated in the pathophysiology
of Parkinson's disease (PD), which might be influenced by successful neuroprotective …
of Parkinson's disease (PD), which might be influenced by successful neuroprotective …
Towards the identification of multi-parametric quantitative MRI biomarkers in lupus nephritis
…, J Torrington, X He, P Hu, PC Chiao… - Magnetic resonance …, 2015 - Elsevier
Purpose To identify potential biomarkers of the renal impairment in lupus nephritis using a
multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (…
multi-parametric renal quantitative MRI (qMRI) protocol including diffusion weighted imaging (…
Comparison of actigraphy and polysomnography to assess effects of zolpidem in a clinical research unit
BT Peterson, P Chiao, E Pickering, J Freeman… - Sleep Medicine, 2012 - Elsevier
OBJECTIVE: This study sought to compare devices that use actigraphy for measuring sleep
endpoints in the clinical research unit (CRU) and home environment. The abilities of …
endpoints in the clinical research unit (CRU) and home environment. The abilities of …