Background Remifentanil (GI87084B) is a new short-acting opioid with a unique ester structure.
Metabolism of remifentanil by ester hydrolysis results in very rapid elimination. The aim …

In the present study, we used positron emission tomography to investigate changes in regional
cerebral blood flow (rCBF) during a general anesthetic infusion set to produce a gradual …

Single-cell technologies have revealed the complexity of the tumour immune microenvironment
with unparalleled resolution 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 – 9 . Most clinical strategies rely on …

Pediatric midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets
identified. Most tumors harbor mutations encoding p.Lys27Met in histone H3 variants. In 40 …

In the present study, we investigated changes in regional cerebral blood flow (rCBF) in
humans during the progression from relaxed wakefulness through slow wave sleep (SWS). …

BACKGROUND: Amb a 1–immunostimulatory phosphorothioate oligonucleotide conjugate (AIC)
is a novel immunotherapeutic compound consisting of purified Amb a 1 from short …

BACKGROUND: ADAM33, a disintegrin and metalloproteinase 33 gene, has been identified
as a risk factor for asthma and bronchial hyperresponsiveness and has been postulated as …

Metastasis is the leading cause of cancer-related deaths, and obesity is associated with
increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose …

Obesity is characterized by chronic systemic inflammation and enhances cancer metastasis
and mortality. Obesity promotes breast cancer metastasis to lung in a neutrophil-dependent …

Different clones, protocol conditions, instruments, and scoring/readout methods may pose
challenges in introducing different PD-L1 assays for immunotherapy. The diagnostic accuracy …