Parkinson's disease (PD) is associated with an abnormal pattern of regional brain function.
The expression of this PD-related covariance pattern (PDRP) has been used to assess …

Early‐onset idiopathic torsion dystonia (ITD) is an autosomal dominant hyperkinetic movement
disorder with incomplete penetrance, associated with a 3 base‐pair deletion in the DYT1 …

The identification of discrete patterns of altered functional brain circuitry in preclinical
Huntington’s disease (HD) gene carriers is important to understanding the pathophysiology of this …

Consistent functional brain abnormalities in Parkinson's disease (PD) are difficult to pinpoint
because differences from the normal state are often subtle. In this regard, the application of …

In the current paper, we describe methodologies for single subject differential diagnosis of
degenerative brain disorders using multivariate principal component analysis (PCA) of …

We tested the hypothesis that the DYT1 genotype is associated with a disorder of anatomical
connectivity involving primarily the sensorimotor cortex. We used diffusion tensor magnetic …

The delineation of resting state networks (RSNs) in the human brain relies on the analysis of
temporal fluctuations in functional MRI signal, representing a small fraction of total neuronal …

PD patients. We then assessthe relationshipbetweenthese
metabolicmeasuresandobjectiveindependentdiseaseseverfty ratings. Methods: …

The scaled subprofile model (SSM)1-4 is a multivariate PCA-based algorithm that identifies
major sources of variation in patient and control group brain image data while rejecting …

We have used [18F]fluorodeoxyglucose and PET to identify specific metabolic covariance
patterns associated with Parkinson's disease and related disorders previously. Nonetheless, …