[HTML][HTML] Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other …
J Rouanet, M Quintana, P Auzeloux, F Cachin… - Pharmacology & …, 2021 - Elsevier
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the production
of melanin. This property means melanin can be considered as a target for monitoring …
of melanin. This property means melanin can be considered as a target for monitoring …
[HTML][HTML] Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment
…, KC Fylaktakidou, A Vidal, P Auzeloux… - Journal of molecular …, 2013 - Springer
Tumor hypoxia is a characteristic of cancer cell growth and invasion, promoting angiogenesis,
which facilitates metastasis. Oxygen delivery remains impaired because tumor vessels …
which facilitates metastasis. Oxygen delivery remains impaired because tumor vessels …
Immune checkpoint inhibitors reverse tolerogenic mechanisms induced by melanoma targeted radionuclide therapy
…, V Benboubker, H Akil, A Hennino, P Auzeloux… - Cancer Immunology …, 2020 - Springer
In line with the ongoing phase I trial (NCT03784625) dedicated to melanoma targeted
radionuclide therapy (TRT), we explore the interplay between immune system and the melanin …
radionuclide therapy (TRT), we explore the interplay between immune system and the melanin …
Quaternary ammonium-melphalan conjugate for anticancer therapy of chondrosarcoma: in vitro and in vivo preclinical studies
…, V Weber, E David, A Vidal, P Auzeloux… - Investigational new …, 2012 - Springer
Cartilage tumours present ongoing therapeutic challenges due to their chondrogenic
extracellular matrix that potentially hampers drug delivery, their low percentage of dividing cells, …
extracellular matrix that potentially hampers drug delivery, their low percentage of dividing cells, …
Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to …
…, J Papon, P Labarre, A Maisonial, P Auzeloux… - Bioorganic & medicinal …, 2008 - Elsevier
Various iodo-acridone and acridine carboxamides have been prepared and evaluated as
agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural …
agents for targeted radionuclide and/or chemotherapy for melanoma, due to their structural …
Small rigid platforms functionalization with quaternary ammonium: targeting extracellular matrix of chondrosarcoma
…, A Vidal, J Morlieras, P Bonazza, P Auzeloux… - … , Biology and Medicine, 2014 - Elsevier
This work takes place in the “cartilage targeting strategy”, consisting in using the quaternary
ammonium (QA) function as a vector to proteoglycans (PGs) of extracellular matrix (ECM). …
ammonium (QA) function as a vector to proteoglycans (PGs) of extracellular matrix (ECM). …
[HTML][HTML] Phase I study of [131I] ICF01012, a targeted radionuclide therapy, in metastatic melanoma: MELRIV-1 protocol
Background Benzamide-based radioligands targeting melanin were first developed for imaging
melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT). [ …
melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT). [ …
Single photon emission computed tomography/positron emission tomography imaging and targeted radionuclide therapy of melanoma: new multimodal fluorinated …
…, R Boisgard, M Bayle, A Vidal, P Auzeloux… - Journal of medicinal …, 2011 - ACS Publications
This study reports a series of 14 new iodinated and fluorinated compounds offering both
early imaging ( 123 I, 124 I, 18 F) and systemic treatment ( 131 I) of melanoma potentialities. …
early imaging ( 123 I, 124 I, 18 F) and systemic treatment ( 131 I) of melanoma potentialities. …
Synthesis, Radiofluorination, and in Vivo Evaluation of Novel Fluorinated and Iodinated Radiotracers for PET Imaging and Targeted Radionuclide Therapy of …
…, E Miot-Noirault, JM Chezal, P Auzeloux - Journal of medicinal …, 2013 - ACS Publications
Our project deals with a multimodal approach using a single fluorinated and iodinated
melanin-targeting structure and offering both imaging (positron emission tomography (PET)/…
melanin-targeting structure and offering both imaging (positron emission tomography (PET)/…
Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [18F]ICF01006, a highly promising melanoma PET tracer
…, E Miot-Noirault, N Moins, P Auzeloux… - European journal of …, 2012 - Springer
Purpose Here, we report a new and rapid radiosynthesis of 18 F-N-[2-(diethylamino)ethyl]-6-fluoro-pyridine-3-carboxamide
([ 18 F]ICF01006), a molecule with a high specificity for …
([ 18 F]ICF01006), a molecule with a high specificity for …