We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein
of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-…

Mounting evidence highlights the role of adipose tissue in the development of a systemic
inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. …

Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of
purified recombinant Acrp30 leads to a 2–3-fold elevation in circulating Acrp30 levels, which …

Although excess visceral fat is associated with noninfectious inflammation, it is not clear
whether visceral fat is simply associated with or actually causes metabolic disease in humans. …

Adipose tissue, when carried around in excessive amounts, predisposes to a large number
of diseases. Epidemiological data show that the prevalence of obesity has significantly …

Over the past two decades our view of adipose tissue has undergone a dramatic change from
an inert energy storage tissue to an active endocrine organ. Adipose tissue communicates …

To fulfill its role as the major energy-storing tissue, adipose has several unique properties
that cannot be seen in any other organ, including an almost unlimited capacity to expand in a …

Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of …

In recent years, we have learned that adipocytes are not merely inert storage depots for
triglycerides but rather highly active cells with potent autocrine, paracrine and endocrine …

Adipose tissue evolved to efficiently store energy for times of caloric restriction. The large
caloric excess common in many Western diets has negated the need for this thrifty function, …