The mammalian hypothalamus strongly influences ingestive behaviour through several
different signalling molecules and receptor systems 1 , 2 , 3 , 4 . Here we show that CART (…

Central administration of the preproglucagon-derived peptide glucagon-like peptide-1
significantly inhibits ingestion of food and water, and glucagon-like peptide-1 binding sites are …

The distribution and biochemical properties of glucagon‐like peptide (GLP)‐1(7–36)amide (GLP‐1)
binding sites in the rat brain were investigated. By receptor autoradiography of …

Within the central nervous system, glucagon-like peptide-1-(7–36) amide (GLP-1) acts as a
transmitter, inhibiting feeding and drinking behavior. Hypothalamic neuroendocrine neurons …

The retinohypothalamic tract (RHT) relays photic information from the eyes to the suprachiasmatic
nucleus (SCN). Activation of this pathway by light plays a role in adjusting circadian …

Background— Although several lines of evidence point to an atherogenic role of central fat
mass (CFM), few data are available to address the specific role played by peripheral fat mass …

Postprandial release of the incretin glucagon-like peptide-1 (GLP-1) has been suggested to
act as an endogenous satiety factor in humans. In rats, however, the evidence for this is …

Background— Upward trends of obesity urge more effective identification of those at
cardiovascular risk. A simple dichotomous indicator, enlarged waist (≥88 cm) combined with …

The novel neuropeptide cocaine–amphetamine-regulated transcript (CART) is expressed in
several hypothalamic regions and has recently been shown to be involved in the central …

Aims To evaluate the safety, pharmacokinetics and pharmacodynamics of SAR425899, a
novel polypeptide, active as an agonist at both the glucagon‐like peptide‐1 receptor (GLP‐1R) …