Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and depressed …

Chronic stress in non-human animals decreases the volume of the hippocampus, a brain
region that supports learning and memory and that regulates neuroendocrine activity. In …

OBJECTIVE: The authors’ goal was to compare regional brain volumes in depressed elderly
subjects with those of nondepressed elderly subjects by using voxel-based morphometry. …

Background: Impulsive aggression in patients with personality disorders is associated with
diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to …

Prefrontal hypoperfusion and decreased glucose uptake in the prefrontal cortex (PFC) are
found in violent criminal offenders, murderers and aggressive psychiatric patients. These …

Departments ofRadiology and Psychiatry, University ofPittsburgh, Pittsburgh, Pennsylvania
significant of these are misregistration of the MR and PET datasets, inaccurate estimation of …

It remains a matter of controversy as to whether cerebral perfusion declines with healthy
aging. In vivo imaging with PET permits quantitative evaluation of brain physiology; however, …

Regional 5-hydroxytryptamine 1A (5-HT 1A ) receptor binding potential (BP) of depressed
subjects with primary, recurrent, familial mood disorders was compared to that of healthy …

OBJECTIVE: To determine whether there are abnormalities in the in vivo status of the serotonin
type 2A (5-HT 2A ) receptor in late-life depression and Alzheimer’s disease, the authors …

Hypertension is a risk factor for diffuse brain atrophy. Yet, there is little evidence that higher
blood pressure predicts focal brain atrophy, as indicated by a lower volume of regional brain …