Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC)
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …

Pioneered with the invention of 11 C-Pittsburgh compound B, amyloid-β imaging using PET
has facilitated research in Alzheimer disease (AD). This imaging approach has promise for …

Purpose: Osimertinib is a potent and selective EGFR tyrosine kinase inhibitor (EGFR-TKI) of
both sensitizing and T790M resistance mutations. To treat metastatic brain disease, blood–…

Poor survival rates of patients with tumors arising from or disseminating into the brain are
attributed to an inability to excise all tumor tissue (if operable), a lack of blood-brain barrier (…

Impaired mitochondrial function, oxidative stress and formation of excessive levels of
reactive oxygen species play a key role in neurodegeneration in Parkinson’s disease. …

J. Neurochem. (2010) 114, 784–794. Abstract Positron emission tomography (PET) radioligands
that bind selectively to β‐amyloid plaques (Aβ) are promising imaging tools aimed at …

Recent reports suggest that an increasing number of patients with lung cancer, especially
those with activating mutations of the epidermal growth factor receptor (EGFR), also present …

A new dopamine receptor antagonist, Raclopride (S-(−)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy-6-methoxybenzamide,
FLA 870) (1), has been labelled using [ 11 C]…

Background The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular response
to DNA damage induced by radiation. ATM inhibition decreases DNA damage repair in …

The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an
Achilles heel that has now rendered this important GTPase druggable. Herein, we report our …