Pigs traditionally are used in surgical and physiological research. Since the development of
the Minnesota minipig in 1949 at the Hormel Institute (USA), miniature pigs have been …

Urodynamic studies in rats and mice are broadly used to examine pathomechnisms of disease
and identify and test therapeutic targets. This review aims to highlight the effects of the …

Since the popular first edition was published more than a decade ago, the number of swine
used in toxicity studies has increased as an alternative to commonly used non-rodent species…

C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO).
Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift …

Delta like 1 (DLK1) has been proposed to act as a regulator of cell fate determination and is
linked to the development of various tissues including skeletal muscle. Herein we further …

Study Design. Glucocorticoid with low calcium and phosphorus intake induces osteopenia in
cancellous bone of sheep. Objective. To validate a large animal model for spine fusion and …

Large animals as sheep are often used as models for human osteoporosis. Our aim was
therefore to determine how glucocorticoid treatment of ovariectomised sheep affects the …

Drawing on the concept of requisite complexity, we propose that mental model complexity is
crucial for teams to thrive in dynamic complex environments. Using a longitudinal research …

Two key questions are addressed in this article. What are the potential harms to minipigs
relative to the harms for dogs and non-human primates and can these harms be reduced more …

The somatostatin receptor, which is overexpressed by many neuroendocrine tumors, is a
well-known target for molecular imaging and peptide receptor radionuclide therapy. Recently, …