Prostate-specific membrane antigen (PSMA)–targeted radiotherapy of prostate cancer (PCa)
has emerged recently as a promising approach to the treatment of disseminated disease. A …

Studies directed at the synthesis of lamellarin G trimethyl ether and ningalin B via vinylogous
iminium salt derivatives are described. The successful strategy relies on the formation of a 2…

Background Xylazine is an α 2-adrenergic agonist that is commonly used as a veterinary
tranquilizer and is increasingly present in the unregulated US drug supply since at least 2019. …

3,5-Dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester is a promising
antitubulin lead agent that targets the colchicine site of tubulin. C-2 analogues were …

The synthesis, biological evaluation and molecular modeling of a series of pyrrole
compounds related to 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid that …

The preparation of an indole appended vinamidinium salt, an indole appended vinylogous
amide and an indole appended chloroenal are described. The subsequent regiospecific …

Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic
acids are described. The successful strategy relies on the preparation of (Z)-3-…

Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with
plasmacytic differentiation. Here, we report the identification of a highly effective inhibitor of PEL. …

The opioid epidemic is an ongoing and worsening public health crisis affecting all age groups,
including adolescents. In 2020, nearly 80 000 adolescents in the United States suffered …

Studies directed at the amine exchange reaction of vinamidinium salts followed by sodium
borohydride reduction to secondary and tertiary allylic amines are described. The tertiary …