Salivary gland dysfunction has been described in patients undergoing radioiodine therapy
but associated lacrimal gland dysfunction (sicca syndrome) has never been reported. We …

To detect the incidence and persistence of potential chromosome damage induced by
iodine-131 therapy, we applied the cytokinesis-block micronucleus assay to peripheral blood …

The role of the DNA repair genes OGG1, XRCC1, XRCC2 and XRCC3 on differentiated thyroid
cancer (DTC) susceptibility was examined in 881 individuals (402 DTC and 479 controls)…

Glutathione S-transferases (GST) are enzymes involved in the metabolism of many
carcinogens and mutagens, also acting as important free-radical scavengers. The existence of …

Several prognostic factors have been proposed to identify the patients at risk to develop
metastases in differentiated thyroid carcinoma. Reduced nm23-H1 expression (a metastatic …

FOXE1 polyalanine tract (poly-Ala) has been associated with thyroid dysgenesis. Recently,
the SNP (rs1867277:-238G> A) within the FOXE1 5’UTR was involved in the genetic …

Basal and induced frequencies of genetic damage can be modulated by different host
factors, including genes involved in phase II metabolism. Since polymorphic variants in the …

Several genes directly related to thyroid cancer development have been described;
nevertheless, the genetic pathways of this tumorigenesis process are unknown. Together with …

The alkaline single-cell gel electrophoresis (SCGE or Comet) assay appears to be a promising
tool for measuring DNA damage at the individual cell level in both in vitro and in vivo …

To provide further data on the possible applications of the single cell gel electrophoresis (SCGE)
or Comet assay in human biomonitoring studies, we have evaluated the eventual …