Dementia is one of the most common and important aspects of Parkinson's disease and has
consequences for patients and caregivers, and has health-related costs. Mild cognitive …

Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified
initially as a major target for dopamine and protein kinase A (PKA) in striatum. However, recent …

A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

The pathophysiology of depression remains enigmatic, although abnormalities in serotonin
signaling have been implicated. We have found that the serotonin 1B receptor [5-…

Alzheimer disease (AD) and Parkinson disease (PD) are the most common neurodegenerative
disorders. For both diseases, early intervention is thought to be essential to the success …

Depression occurs in around 35% of patients with Parkinson disease (PD) and is often
persistent. Symptoms of depression can be evident in individuals at the time of diagnosis and …

Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake
at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny …

… per kg of body weight SKF 81297 (Tocris), 0.2 mg per kg quinpirole, 7.5 mg per kg caffeine,
25 mg per kg cocaine, 1 mg per kg haloperidol and 5 mg per kg clozapine (all from Sigma). …

The ascending serotonin (5-HT) neurons innervate the cerebral cortex, hippocampus, septum
and amygdala, all representing brain regions associated with various domains of cognition…

Three distinct classes of drugs: dopaminergic agonists (such as D-amphetamine),
serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce …