[HTML][HTML] Moving oncolytic viruses into the clinic: clinical-grade production, purification, and characterization of diverse oncolytic viruses

G Ungerechts, S Bossow, B Leuchs, PS Holm… - … Therapy Methods & …, 2016 - cell.com
Oncolytic viruses (OVs) are unique anticancer agents based on their pleotropic modes of
action, which include, besides viral tumor cell lysis, activation of antitumor immunity. A panel of …

[HTML][HTML] YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter

PS Holm, S Bergmann, K Jurchott, H Lage… - Journal of Biological …, 2002 - ASBMB
The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication,
and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here …

Systemic image-guided liver cancer radiovirotherapy using dendrimer-coated adenovirus encoding the sodium iodide symporter as theranostic gene

…, C Zach, E Wagner, B Göke, PS Holm… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Currently, major limitations for the clinical application of adenovirus-mediated gene therapy
are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-…

Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase

A Ludwig, G Saretzki, PS Holm, F Tiemann, M Lorenz… - Cancer Research, 2001 - AACR
Telomerase activity is necessary and sufficient for immortality in many cells and hence
represents a prime target for antitumor strategies. Here, we show that a hammerhead ribozyme …

[HTML][HTML] EGFR-targeted adenovirus dendrimer coating for improved systemic delivery of the theranostic NIS gene

…, C Zach, E Wagner, B Göke, PS Holm… - … Therapy-Nucleic Acids, 2013 - cell.com
We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined
radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) …

CDK4/6 inhibition controls proliferation of bladder cancer and transcription of RB1

…, SM Schwarzenböck, BJ Krause, PS Holm… - The Journal of …, 2016 - auajournals.org
Purpose : The retinoblastoma signaling network is frequently altered in advanced bladder
cancer. We investigated the potential of CDK4/6 as a therapeutic target and determined …

Multidrug-resistant cancer cells facilitate E1-independent adenoviral replication: impact for cancer gene therapy

PS Holm, H Lage, S Bergmann, K Jürchott… - Cancer research, 2004 - AACR
Resistance to chemotherapy is responsible for a failure of current treatment regimens in
cancer patients. We have reported previously that the Y-box protein YB-1 regulates expression …

Novel three-pronged strategy to enhance cancer cell killing in glioblastoma cell lines: histone deacetylase inhibitor, chemotherapy, and oncolytic adenovirus dl520

…, H Lage, B Gansbacher, PS Holm - Human gene …, 2006 - liebertpub.com
Resistance to radiation and chemotherapy remains an obstacle to the treatment of brain
tumors. We have demonstrated that the replication-deficient adenovirus d1520, which lacks the …

Adenoviral vectors coated with PAMAM dendrimer conjugates allow CAR independent virus uptake and targeting to the EGF receptor

…, W Rödl, E Wagner, PS Holm… - Molecular …, 2013 - ACS Publications
Adenovirus type 5 (Ad) is an efficient gene vector with high gene transduction potential, but
its efficiency depends on its native cell receptors coxsackie- and adenovirus receptor (CAR) …

Inhibition of the multidrug-resistant phenotype by targeting YB-1 with a conditionally oncolytic adenovirus: implications for combinatorial treatment regimen with …

…, U Treiber, R Hartung, B Gansbacher, PS Holm - Cancer research, 2006 - AACR
Bearing in mind the limited success of available treatment modalities for the therapy of
multidrug-resistant tumor cells, alternative and complementary strategies need to be developed. It …