In Vivo Imaging of Prostate Cancer Using [68Ga]-Labeled Bombesin Analog BAY86-7548
…, K Lehtiö, TJ Grönroos, A Kuisma, P Luoto… - Clinical cancer …, 2013 - AACR
Purpose: A novel [ 68 Ga]-labeled DOTA-4-amino-1-carboxymethyl-piperidine-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH
2 peptide (BAY86-7548) having high affinity to bombesin …
2 peptide (BAY86-7548) having high affinity to bombesin …
Quantification of [18F]DPA-714 Binding in the Human Brain: Initial Studies in Healthy Controls and Alzheimer'S Disease Patients
…, J Virta, M Haaparanta-Solin, P Luoto… - Journal of Cerebral …, 2015 - journals.sagepub.com
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide
([ 18 F] DPA-714) binds to the 18-kDa translocator protein (TSPO) …
([ 18 F] DPA-714) binds to the 18-kDa translocator protein (TSPO) …
Plasma pharmacokinetics, whole-body distribution, metabolism, and radiation dosimetry of 68Ga bombesin antagonist BAY 86-7548 in healthy men
A Roivainen, E Kähkönen, P Luoto… - Journal of Nuclear …, 2013 - Soc Nuclear Med
This first-in-human study investigated the safety, tolerability, metabolism, pharmacokinetics,
biodistribution, and radiation dosimetry of 68 Ga-bombesin antagonist 68 Ga-DOTA-4-amino-…
biodistribution, and radiation dosimetry of 68 Ga-bombesin antagonist 68 Ga-DOTA-4-amino-…
Adenosine A2A receptors in secondary progressive multiple sclerosis: a [11C] TMSX brain PET study
…, J Tuisku, S Helin, P Luoto… - Journal of Cerebral …, 2013 - journals.sagepub.com
In this study, positron emission tomography (PET) imaging with a radioligand to adenosine
A2A receptors (A2AR)—a potent regulator of inflammation—was used to gain insight into the …
A2A receptors (A2AR)—a potent regulator of inflammation—was used to gain insight into the …
[HTML][HTML] Prospective study on the effect of short-term androgen deprivation therapy on PSMA uptake evaluated with 68Ga-PSMA-11 PET/MRI in men with treatment …
O Ettala, S Malaspina, T Tuokkola, P Luoto… - European Journal of …, 2020 - Springer
Purpose Based on in vitro studies, it is known that androgen deprivation therapy (ADT)
increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised …
increases prostate-specific membrane antigen (PSMA) expression. Therefore, we hypothesised …
Comparison of somatostatin receptor 2-targeting PET tracers in the detection of mouse atherosclerotic plaques
…, J Virta, XG Li, M Käkelä, K Helariutta, P Luoto… - Molecular Imaging and …, 2016 - Springer
Purpose Rupture-prone atherosclerotic plaques are characterized by accumulation of
macrophages, which have shown to express somatostatin type 2 receptors. We aimed to …
macrophages, which have shown to express somatostatin type 2 receptors. We aimed to …
68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice
J Haukkala, I Laitinen, P Luoto, P Iveson… - European journal of …, 2009 - Springer
Purpose Increased expression of αvβ3/αvβ5 integrin is involved in angiogenesis and the
inflammatory process in atherosclerotic plaques. The novel 68 Ga-DOTA-RGD peptide binds …
inflammatory process in atherosclerotic plaques. The novel 68 Ga-DOTA-RGD peptide binds …
Uptake of 11C-choline in mouse atherosclerotic plaques
IEK Laitinen, P Luoto, K Någren… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The purpose of this study was to explore the feasibility of 11 C-choline in the assessment of
the degree of inflammation in atherosclerotic plaques. Methods: Uptake of 11 C-choline was …
the degree of inflammation in atherosclerotic plaques. Methods: Uptake of 11 C-choline was …
[HTML][HTML] Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT
M Lahesmaa, V Oikonen, S Helin, P Luoto… - European journal of …, 2019 - Springer
Purpose Brown adipose tissue (BAT) has emerged as a potential target to combat obesity
and diabetes, but novel strategies to activate BAT are needed. Adenosine and A 2A receptor (…
and diabetes, but novel strategies to activate BAT are needed. Adenosine and A 2A receptor (…
Automated Reference Region Extraction and Population-Based Input Function for Brain [11C]TMSX PET Image Analyses
E Rissanen, J Tuisku, P Luoto… - Journal of Cerebral …, 2015 - journals.sagepub.com
[ 11 C]TMSX ([7-N-methyl- 11 C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine) is a
selective adenosine A2A receptor (A 2A R) radioligand. In the central nervous system (CNS), …
selective adenosine A2A receptor (A 2A R) radioligand. In the central nervous system (CNS), …