Purpose: Glioblastoma multiforme is a highly aggressive form of brain cancer whose
location, tendency to infiltrate healthy surrounding tissue, and heterogeneity significantly limit …

Purpose: We performed a first-in-human clinical trial. The aim of this study was to determine
safety and feasibility of PET imaging with 18 F-PARPi in patients with head and neck cancer. …

We report an innovative approach to producing bacteriochlorins (bacs) via formal cycloaddition
by subjecting a porphyrin to a trimolecular reaction. Bacs are near-infrared probes with …

For oral, oropharyngeal and oesophageal cancer, the early detection of tumours and of residual
tumour after surgery are prognostic factors of recurrence rates and patient survival. Here…

Background We report preclinical and first-in-human-brain-cancer data using a targeted poly
(ADP-ribose) polymerase 1 (PARP1) binding PET tracer, [ 18 F]PARPi, as a diagnostic tool …

Background Visual inspection and biopsy is the current standard of care for oral cancer
diagnosis, but is subject to misinterpretation and consequently to misdiagnosis. Topically applied …

The human nociceptor-specific voltage-gated sodium channel 1.7 (hNa V 1.7) is critical for
sensing various types of somatic pain, but it appears not to play a primary role in acute …

Complete removal and negative margins are the goal of any surgical resection of primary
oral cavity carcinoma. Current approaches to determine tumor boundaries rely heavily on …

Background Segmental mandibulectomy impairs health‐related quality of life (QoL), by
altering speech, mastication, swallowing, and facial aesthetics. Fibula free flap (FFF) used for …

Purpose: We investigated reflectance confocal microscopy (RCM) as a possible non-invasive
approach for the diagnosis of cancer and real-time assessment of surgical margins. …