An eighteen‐membered macrocyclic ligand for actinium‐225 targeted alpha therapy
…, C Rodríguez‐Rodríguez, P Schaffer… - Angewandte Chemie …, 2017 - Wiley Online Library
The 18‐membered macrocycle H 2 macropa was investigated for 225 Ac chelation in
targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar …
targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar …
The medicinal chemistry of carboranes
…, KJ Guenther, AS King, P Morel, P Schaffer… - Coordination Chemistry …, 2002 - Elsevier
The medicinal chemistry of dicarba-closo-dodecaboranes (otherwise referred to as carboranes)
has traditionally centered on their use in boron neutron capture therapy (BNCT). More …
has traditionally centered on their use in boron neutron capture therapy (BNCT). More …
Development of the as-cast microstructure in magnesium–aluminium alloys
AK Dahle, YC Lee, MD Nave, PL Schaffer… - Journal of light metals, 2001 - Elsevier
This paper presents an overview of several projects undertaken at CAST to increase our
understanding of the solidification characteristics of Mg–Al alloys. With the increased use of …
understanding of the solidification characteristics of Mg–Al alloys. With the increased use of …
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells
RS Bindra, PJ Schaffer, A Meng, J Woo… - … and cellular biology, 2004 - Taylor & Francis
There is an emerging concept that acquired genetic instability in cancer cells can arise from
the dysregulation of critical DNA repair pathways due to cell stresses such as inflammation …
the dysregulation of critical DNA repair pathways due to cell stresses such as inflammation …
Descriptive epidemiology of cerebral gliomas in France
…, JP Daures, M Henry‐Amar, N Raverdy, P Schaffer… - Cancer, 1997 - Wiley Online Library
BACKGROUND Descriptive epidemiology of cerebral gliomas has recently been the subject
of several studies, indicating a possible increase in brain tumor rates, particularly in the …
of several studies, indicating a possible increase in brain tumor rates, particularly in the …
Development of 225Ac radiopharmaceuticals: TRIUMF perspectives and experiences
…, CF Ramogida, P Schaffer… - Current …, 2018 - ingentaconnect.com
Background: The development of radiopharmaceuticals containing 225Ac for targeted
alpha therapy is an active area of academic and commercial research worldwide. Objectives: …
alpha therapy is an active area of academic and commercial research worldwide. Objectives: …
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
…, WW Lockwood, P Schaffer… - Proceedings of the …, 2019 - National Acad Sciences
The RAS family of proto-oncogenes are among the most commonly mutated genes in human
cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic …
cancers and predict poor clinical outcome. Several mechanisms underlying oncogenic …
Cyclotron production of 99mTc: experimental measurement of the 100Mo (p, x) 99Mo, 99mTc and 99gTc excitation functions from 8 to 18 MeV
INTRODUCTION: The cyclotron-based 100 Mo(p,2n) 99m Tc transformation has been
proposed as a viable alternative to the reactor based 235 U(n,f) 99 Mo→ 99m Tc strategy for …
proposed as a viable alternative to the reactor based 235 U(n,f) 99 Mo→ 99m Tc strategy for …
Infrared Spectroscopic Investigations of Zeolites and Adsorbed Molecules. II. Adsorbed Carbon Monoxide1
CL Angell, PC Schaffer - The Journal of Physical Chemistry, 1966 - ACS Publications
On adsorbing carbon monoxide on X-and Y-type zeolites containing a variety of cations, two
types of adsorption can be observed by infrared spectroscopy. The first, occurring on …
types of adsorption can be observed by infrared spectroscopy. The first, occurring on …
Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study.
…, A Bingham, P Amouyel, P Schaffer… - … and Thrombosis: A …, 1994 - Am Heart Assoc
Human apolipoprotein (apo) E, a polymorphic protein with three common alleles, epsilon 2,
epsilon 3, and epsilon 4, plays an important role in lipoprotein metabolism. This article …
epsilon 3, and epsilon 4, plays an important role in lipoprotein metabolism. This article …