Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat

M Itoh, PH Guth - Gastroenterology, 1985 - Elsevier
This study was designed to determine whether oxygen-derived free radicals play a role in
the pathogenesis of gastric lesions produced by hypotensive ischemia in the rat. To achieve …

Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection

PH Guth, G Paulsen, H Nagata - Gastroenterology, 1984 - Elsevier
The effect of 16,16-dimethyl prostaglandin E 2 (dmPGE 2 ) on histologic and microcirculatory
changes in alcohol-induced gastric mucosal injury was studied. A histologic study …

[PDF][PDF] Contribution of no‐reflow phenomenon to hepatic injury after ischemia‐reperfusion: evidence for a role for superoxide anion

A Koo, H Komatsu, G Tao, M Inoue, PH Guth… - …, 1992 - Wiley Online Library
Controversy exists as to the role of oxygen‐derived free radicals in tissue injury and the no‐reflow
phenomenon in reperfusion injury after ischemia. In this study using an experimental …

A proof-of-principle, prospective, randomized, controlled trial demonstrating improved outcomes in scheduled unsedated colonoscopy by the water method

…, NJ Jamgotchian, HS Aharonian, PH Guth… - Gastrointestinal …, 2010 - Elsevier
BACKGROUND: An observational study in veterans showed that a novel water method (water
infusion in lieu of air insufflation) enhanced cecal intubation and willingness to undergo a …

Microcirculation of the islets of Langerhans: Long Beach Veterans Administration Regional Medical Education Center Symposium

…, H Wayland, R Kelinman, E Livingston, P Guth… - Diabetes, 1996 - go.gale.com
To discuss the controversy of the current concept of islet microcirculation, an international
symposium was held at the Long Beach Veterans Administration Regional Medical Education …

Sensory neurons mediate protective vasodilatation in rat gastric mucosa

…, EH Livingston, A Saria, PH Guth - American Journal of …, 1991 - journals.physiology.org
Sensory nerve stimulation by intragastric capsaicin (160 microM) prevents ethanol injury to
the gastric mucosa and facilitates gastric mucosal blood flow (GMBF). The present study …

Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

M Mizumori, M Ham, PH Guth, E Engel… - The Journal of …, 2009 - Wiley Online Library
Regulation of localized extracellular pH (pH o ) maintains normal organ function. An alkaline
microclimate overlying the duodenal enterocyte brush border protects the mucosa from …

Vascular Dysfunction and Ischemic Destruction of Tissue in Streptococcus pyogenes Infection: The Role of Streptolysin O–Induced Platelet/Neutrophil Complexes

…, CR Bayer, RYZ Chen, PH Guth… - The Journal of …, 2005 - academic.oup.com
Rapid tissue destruction in group A streptococcal (GAS) necrotizing fasciitis/myonecrosis
often necessitates extensive debridement to ensure survival. The mechanisms responsible for …

Clostridial Gas Gangrene. II. Phospholipase C—Induced Activation of Platelet gpIIbIIIa Mediates Vascular Occlusion and Myonecrosis in Clostvidium perfringens Gas …

…, Y Wang, CH Lee, S Finegold, PH Guth… - The Journal of …, 2000 - academic.oup.com
Clostridium perfringens gas gangrene is a fulminant infection, and radical amputation remains
the single best treatment. It has been hypothesized that rapid tissue destruction is related …

Short‐chain fatty acid sensing in rat duodenum

…, K Iwamoto, M Watanabe, PH Guth… - The Journal of …, 2015 - Wiley Online Library
Key points Luminal lipid in the duodenum modulates gastroduodenal functions via the release
of gut hormones and mediators such as cholecystokinin and 5‐HT. The effects of luminal …