68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer

C Kratochwil, P Flechsig, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The recent development of quinoline-based PET tracers that act as fibroblast-activation-protein
inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …

68Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers

…, W Lehnert, J Debus, D Jäger, P Flechsig… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of
several tumor entities. The recent development of quinoline-based PET tracers that act as FAP …

Detection efficacy of 18F-PSMA-1007 PET/CT in 251 patients with biochemical recurrence of prostate cancer after radical prostatectomy

…, F Spohn, L Will, T Maurer, P Flechsig… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–targeted PET imaging recently emerged as a
new method for the staging and restaging of prostate cancer. Most published studies …

[HTML][HTML] FAPI-74 PET/CT using either 18F-AlF or cold-kit 68Ga labeling: biodistribution, radiation dosimetry, and tumor delineation in lung cancer patients

…, R El Shafie, M Röhrich, P Flechsig… - Journal of Nuclear …, 2021 - Soc Nuclear Med
68 Ga-fibroblast activation protein inhibitors (FAPIs) 2, 4, and 46 have already been proposed
as promising PET tracers. However, the short half-life of 68 Ga (68 min) creates problems …

LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals

P Flechsig, M Dadrich, S Bickelhaupt, J Jenne… - Clinical Cancer …, 2012 - AACR
Purpose: Radiotherapy is used for the treatment of lung cancer, but at the same time
induces acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling is …

Fibroblast activation protein–specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study

…, AK Wefers, O Weinheimer, P Flechsig… - Journal of nuclear …, 2022 - Soc Nuclear Med
Interstitial lung diseases (ILDs) comprise over 200 parenchymal lung disorders. Among
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …

Local recurrence of prostate cancer after radical prostatectomy is at risk to be missed in 68Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI …

…, K Wieczorek, C Sachpekidis, P Flechsig… - European journal of …, 2017 - Springer
Purpose The positron emission tomography (PET) tracer 68 Ga-PSMA-11, targeting the
prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads …

Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis

…, U Wirkner, M Dadrich, P Flechsig… - JNCI: Journal of the …, 2017 - academic.oup.com
Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce
pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (…

IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein–specific PET/CT

…, P Windisch, T Hielscher, P Flechsig… - European journal of …, 2019 - Springer
Purpose Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing
the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. …

Repeated 177Lu-labeled PSMA-617 radioligand therapy using treatment activities of up to 9.3 GBq

H Rathke, FL Giesel, P Flechsig, K Kopka… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Current treatment protocols for 177 Lu-labeled PSMA-617 therapies were cautiously derived
from dosimetry data, but their practical appropriateness has not yet been proven clinically. …