68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer
C Kratochwil, P Flechsig, T Lindner… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The recent development of quinoline-based PET tracers that act as fibroblast-activation-protein
inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is …
68Ga-FAPI PET/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers
…, W Lehnert, J Debus, D Jäger, P Flechsig… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts of
several tumor entities. The recent development of quinoline-based PET tracers that act as FAP …
several tumor entities. The recent development of quinoline-based PET tracers that act as FAP …
Detection efficacy of 18F-PSMA-1007 PET/CT in 251 patients with biochemical recurrence of prostate cancer after radical prostatectomy
…, F Spohn, L Will, T Maurer, P Flechsig… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–targeted PET imaging recently emerged as a
new method for the staging and restaging of prostate cancer. Most published studies …
new method for the staging and restaging of prostate cancer. Most published studies …
[HTML][HTML] FAPI-74 PET/CT using either 18F-AlF or cold-kit 68Ga labeling: biodistribution, radiation dosimetry, and tumor delineation in lung cancer patients
…, R El Shafie, M Röhrich, P Flechsig… - Journal of Nuclear …, 2021 - Soc Nuclear Med
68 Ga-fibroblast activation protein inhibitors (FAPIs) 2, 4, and 46 have already been proposed
as promising PET tracers. However, the short half-life of 68 Ga (68 min) creates problems …
as promising PET tracers. However, the short half-life of 68 Ga (68 min) creates problems …
LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals
P Flechsig, M Dadrich, S Bickelhaupt, J Jenne… - Clinical Cancer …, 2012 - AACR
Purpose: Radiotherapy is used for the treatment of lung cancer, but at the same time
induces acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling is …
induces acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling is …
Fibroblast activation protein–specific PET/CT imaging in fibrotic interstitial lung diseases and lung cancer: a translational exploratory study
…, AK Wefers, O Weinheimer, P Flechsig… - Journal of nuclear …, 2022 - Soc Nuclear Med
Interstitial lung diseases (ILDs) comprise over 200 parenchymal lung disorders. Among
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …
them, fibrosing ILDs, especially idiopathic pulmonary fibrosis, are associated with a poor …
Local recurrence of prostate cancer after radical prostatectomy is at risk to be missed in 68Ga-PSMA-11-PET of PET/CT and PET/MRI: comparison with mpMRI …
…, K Wieczorek, C Sachpekidis, P Flechsig… - European journal of …, 2017 - Springer
Purpose The positron emission tomography (PET) tracer 68 Ga-PSMA-11, targeting the
prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads …
prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads …
Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis
…, U Wirkner, M Dadrich, P Flechsig… - JNCI: Journal of the …, 2017 - academic.oup.com
Background: Radiotherapy is a mainstay for the treatment of lung cancer that can induce
pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (…
pneumonitis or pulmonary fibrosis. The matricellular protein connective tissue growth factor (…
IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein–specific PET/CT
…, P Windisch, T Hielscher, P Flechsig… - European journal of …, 2019 - Springer
Purpose Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing
the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. …
the visualization of tumor stroma. Here, we applied FAP-specific PET imaging to gliomas. …
Repeated 177Lu-labeled PSMA-617 radioligand therapy using treatment activities of up to 9.3 GBq
H Rathke, FL Giesel, P Flechsig, K Kopka… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Current treatment protocols for 177 Lu-labeled PSMA-617 therapies were cautiously derived
from dosimetry data, but their practical appropriateness has not yet been proven clinically. …
from dosimetry data, but their practical appropriateness has not yet been proven clinically. …